DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and AgaP_AGAP005096

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_313972.3	Gene:	AgaP_AGAP005096 / 1274771	VectorBaseID:	AGAP005096	Length:	898	Species:	Anopheles gambiae

Alignment Length:	627	Identity:	153/627 - (24%)
Similarity:	221/627 - (35%)	Gaps:	202/627 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PHSLSPST--------------PILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNLNALASQH 134
            ||.|...|              |.|.|..||..:|..:         ........||...:...:
Mosquito   237 PHQLPSPTHPSQHQLALHHAQHPALGQQQPPHPSLAEL---------EYMKTLKETNKYFIDRNY 292

  Fly   135 RLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGS--KPKVATPTVV-------SKIE 190
            |.|..:. |:||        ..:|......||....|..||.  :..:::||..       |...
Mosquito   293 RSLGYAA-GMRG--------GPEGPPEDGTGTSAGGGASGGGEYEENLSSPTGAGSGNGSGSLKR 348

  Fly   191 QYKRENPTIFAWEIRER------------LITEGVCTNATAPSVSSINRILRNRAAERAAAEFAR 243
            :|.|..      :..:|            |:.:|..:|.|  |.||||:.  |:..| :|.:..|
Mosquito   349 KYDRTR------DGEDRPGGNGGNGDGGVLLPDGSESNPT--SDSSINKY--NKLHE-SADKSIR 402

  Fly   244 AASYGY---------------------------------------AIHPTHPHPYTSFPTWPAHH 269
            |.|:.|                                       .:|.......|......:.|
Mosquito   403 ANSFDYMKNFDELRARQAAAYEAEQHHHHHQQQQQQQQHHHQQLQVLHQQQQQQQTQQHLSQSQH 467

  Fly   270 PLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGD 334
            |                     .||..|...:|:..       .:|:.|...|.|..::.|| .|
Mosquito   468 P---------------------QQPSPSSGQHGTTA-------GTNAGTDDYNPHRQSADSG-AD 503

  Fly   335 SSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSD--QPKFRRNRTTFSPEQLD 397
            ..|..|.:|..     |....:::..::....:. .|.|.|..|.:  :.|.|||||||:..||.
Mosquito   504 KGADDGGVSYA-----SSEELNQTTSSEQGEKVG-SGSDDEGGDDNCSKKKHRRNRTTFTTYQLH 562

  Fly   398 ELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIK----------QRD 452
            |||:.|:|||||.|.:||:||.:..|.|.||||||.||||||||.::...::          .|.
Mosquito   563 ELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLSHFSQLPHRL 627

  Fly   453 SPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQP---YP-YST-------SN--MCNTSS 504
            |.:..:.|   |:|.:||      |:..|:|  |....|   || |.|       ||  |.|...
Mosquito   628 SCNGGNLP---VDPWLSP------PLLSALP--GFLSHPQGVYPSYLTPPLSLNPSNLGMTNLGL 681

  Fly   505 SSSNSQPCNTINPGSKMSSKTS-----------------SVSSNQHM----EEPAAAVATASPTA 548
            ...|......|:|.| |::.||                 |:...|::    :.|.......:|..
Mosquito   682 GHPNGPQNLRISPQS-MAAMTSPQMTAGSMRLSPPHVNGSLGGPQNLSMPHQPPPGPHGPLTPRH 745

  Fly   549 SAPLSMGGENSAFRALPMTLP-----MPMTLPTASAAAFALS 585
            | ||..|...|...:.|..||     .|:|:|.||....:|:
Mosquito   746 S-PLEAGPLGSLTGSQPPPLPPTAGSTPITIPVASPQNLSLT 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	26/116 (22%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
AgaP_AGAP005096	XP_313972.3	Homeobox	553..605	CDD:278475	33/51 (65%)
AgaP_AGAP005096	XP_313972.3	OAR	870..886	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910