DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Lhx5

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_620605.1	Gene:	Lhx5 / 124451	RGDID:	71079	Length:	402	Species:	Rattus norvegicus

Alignment Length:	282	Identity:	65/282 - (23%)
Similarity:	95/282 - (33%)	Gaps:	109/282 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 NSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSP-DADANRMIDIEGEDSESQDSDQPKFRRN-RT 389
            ||.|.|.|.|          ||||........| :.|.:...|.|..::|:::.:....||. ||
  Rat   131 NSVSSCTDRS----------LSPDLQDPLQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRT 185

  Fly   390 TFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQR--- 451
            |...:||:.|:..|..:..|..:.||:||..|.|:...:||||.|||:|.||.::::.:..|
  Rat   186 TIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHA 250

  Fly   452 ------------------------------------------------DSPSTSSSPT------- 461
                                                            ..||.:.||.
  Rat   251 FFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQSDYYAPGGNYDFFAHGPPSQAQSPADSSFLAA 315

  Fly   462 -------------PLVNP-----------VVSPVSPIPVP-VPVAVPE------SGQQKQPYPYS 495
                         ||..|           :..|.:|.|.| :|.|:..      ||....|:|
  Rat   316 SGPGSTPLGALEPPLAGPHGADNPRFTDMISHPDTPSPEPGLPGALHPMPGEVFSGGPSPPFP-- 378

  Fly   496 TSNMCNTSSSSSNSQPCNTINP 517
                  .|.:|..|.|.:..||
  Rat   379 ------MSGTSGYSGPLSHPNP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
Lhx5	NP_620605.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753
		LIM2_Lhx1_Lhx5	64..119	CDD:188761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		18/64 (28%)
		Homeobox	183..237	CDD:395001	22/53 (42%)
		PHA03378	<247..>392	CDD:223065	22/152 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		23/105 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910