Protein Alignment toe and Nkx2-5

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_446103.2
• Gene: Nkx2-5 / 114109
• RGDID: 620520
• Length: 319
• Species: Rattus norvegicus
• Alignment Length: 407
• Identity: 81/407 - (19%)
• Similarity: 125/407 - (30%)
• Gaps: 160/407 - (39%)

  Fly   182 TPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRILRNRA---AERAAAEFAR 243
            ||..|..|...:::..::.|.::..||       .||....|.:....:..|   .|.||...|.
  Rat    10 TPFSVKDILNLEQQQRSLAAGDLSARL-------EATLAPASCMLAAFKPEAYSGPEAAAPGLAE 67

  Fly   244 -AASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNM 307
             .|..|.|  |:.|....:|||.|..:|                            .:||
  Rat    68 LRAELGPA--PSPPKCSPAFPTAPTFYP----------------------------RAYG----- 97

  Fly   308 SSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMI----D 368
                                                    .||    .::.|.||...:.    .
  Rat    98 ----------------------------------------DPD----PAKDPRADKKELCALQKA 118

  Fly   369 IEGEDSESQDSDQPKFRRN---RTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQV 430
            :|.:.:|:..:::|:.||.   |..||..|:.|||:.|.:..|.....|::||:...|:..:|::
  Rat   119 VELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKI 183

  Fly   431 WFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPV----------------- 478
            ||.|||.|.:|.::...::             |:.|...|...|.|||
  Rat   184 WFQNRRYKCKRQRQDQTLE-------------LLGPPPPPARRIAVPVLVRDGKPCLGDSAAYAP 235

  Fly   479 --PVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAV 541
              .|.:...|....|||......|:.:.|      |                         |||.
  Rat   236 AYGVGLNAYGYNAYPYPGYGGAACSPAYS------C-------------------------AAAY 269

  Fly   542 ATASPTASAPLSMGGEN 558
            ..|.|.|..|.:....|
  Rat   270 PAAPPAAQPPAAAANSN 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	10/47 (21%)
		Homeobox	388..440	CDD:278475	20/51 (39%)
Nkx2-5	NP_446103.2	Homeobox	144..194	CDD:395001	19/49 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910