DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Prrx2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001099209.1	Gene:	Prrx2 / 113931	RGDID:	1311471	Length:	248	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	83/293 - (28%)
Similarity:	116/293 - (39%)	Gaps:	94/293 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 PPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSL 344
            ||..||   |....||...              .:..|.:.|:..:....:..|..:||
  Rat    12 PPAPGP---GPPPAPGDCA--------------QARKNFSVSHLLDLEEVAAAGRRAAG------ 53

  Fly   345 PALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSD------------QPKFRRNRTTFSPEQLD 397
            |...|::....:|.|...::      |.::..||.:            :.|.|||||||:..||.
  Rat    54 PVPGPEAREGAAREPSGGSS------GSEAAPQDGECAAPGHGSATKRKKKQRRNRTTFNSSQLQ 112

  Fly   398 ELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNL--------------- 447
            .||:.|:::|||....||:||.|..||||||||||.|||||:||::|..|
  Rat   113 ALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLATRSASLLKSYGQEA 177

  Fly   448 -IKQRDSP-STSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQ 510
             |:|..:| .|:.||..|..|..||.|.:|                 ||          |...|.
  Rat   178 AIEQPVAPRPTTLSPDYLSWPASSPYSSVP-----------------PY----------SPGGSS 215

  Fly   511 PCNTINPGSKMSSKTSSVS------SNQHMEEP 537
            |.   .||..|::..:|:.      |..|.:.|
  Rat   216 PA---TPGVNMANSIASLRLKAKEFSLHHSQVP 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	32/51 (63%)
Prrx2	NP_001099209.1	Homeobox	104..156	CDD:395001	31/51 (61%)
		COG5576	<110..214	CDD:227863	47/130 (36%)
		OAR	222..238	CDD:397759	2/15 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910