DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and VAX1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001106175.1	Gene:	VAX1 / 11023	HGNCID:	12660	Length:	334	Species:	Homo sapiens

Alignment Length:	342	Identity:	80/342 - (23%)
Similarity:	120/342 - (35%)	Gaps:	105/342 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 HSNGH----NTNSGSGCGDSSAGSGRLSLPALSPDSG-------------SRDSRSPDADANRMI 367
            ||:..    :.|:.....:|....|.|....|....|             |:.:.:.|.|..|.|
Human    13 HSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADPDYCRRI 77

  Fly   368 ---DIEGEDSE-----SQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALS 424
               |.:|...|     ..|.|:||  |.||:|:.|||..||.||.:..|.....|.:||.:..||
Human    78 LVRDAKGSIREIILPKGLDLDRPK--RTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLS 140

  Fly   425 EARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPI----------PVPVP 479
            |.:|:|||.|||.|.::.|      .:||...|     :|:...:..|.:          |..:|
Human   141 ETQVKVWFQNRRTKQKKDQ------GKDSELRS-----VVSETAATCSVLRLLEQGRLLSPPGLP 194

  Fly   480 VAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATA 544
            ..:|                           ||.|...||.:...:............|||.|.|
Human   195 ALLP---------------------------PCATGALGSALRGPSLPALGAGAAAGSAAAAAAA 232

  Fly   545 SP-----TASAPLSMGGENSAFRALP--------------MTLPMPMTL----------PTASAA 580
            :|     .:..|.::||......|.|              .:||:|..|          |...|.
Human   233 APGPAGAASPHPPAVGGAPGPGPAGPGGLHAGAPAAGHSLFSLPVPSLLGSVASRLSSAPLTMAG 297

  Fly   581 AFALSFARQYIAKYMGT 597
            :.|.:. ::..|:|:.:
Human   298 SLAGNL-QELSARYLSS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	25/51 (49%)
VAX1	NP_001106175.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		6/27 (22%)
		COG5576	66..184	CDD:227863	43/130 (33%)
		Homeobox	103..157	CDD:365835	25/53 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..263		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..334		80/342 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910