Protein Alignment toe and CPHXL

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001342542.1
• Gene: CPHXL / 105371346
• HGNCID: 51815
• Length: 405
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 56/280 - (20%)
• Similarity: 101/280 - (36%)
• Gaps: 70/280 - (25%)

  Fly   370 EGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSN 434
            |...:|.:.:...:..::|..||.|.|.||::.|.::.||...||:.||.:.......:..||.|
Human    14 EDHHNEERQTKNKRKTKHRHKFSEELLQELKEIFGENCYPDYTTRKTLAIKFDCPVNVIDNWFQN 78

  Fly   435 RRAKW---RRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPE--SGQQK----- 489
            :||:.   .|.:...|.|:.|.|..:.|       .:|...........|..:  ||.|:
Human    79 KRARLPPAERRRIFVLQKKHDFPVQAHS-------FLSCQETQAAAHNYATKQSLSGAQRALMRR 136

  Fly   490 -------------QPYPYSTSNMCNTSSSSSNSQP------------------CNTIN----PGS 519
                         |...|:..::.|..:.|....|                  |:.:.    |..
Human   137 AGCSHLEKQWIPSQEMGYNCFSLENQETPSQQVGPQCSYLEKPGIPSQQVGSQCSYLEKLGIPSQ 201

  Fly   520 KMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTL-----PMPMTLP---- 575
            :::|::|.:.:... :.|..|:.....|.|.. |..|.::|:..|....     |.|.::|
Human   202 QVASQSSYLVTGTE-KHPGCAMGYGGDTGSGH-SGSGHSTAYHFLSYNSAECLHPPPSSVPYFHG 264

  Fly   576 -------TASAAAFALSFAR 588
                   :..|:.|.|.:|:
Human   265 ERTETKESQHASPFLLDYAQ 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197
		Homeodomain	385..441	CDD:459649	19/58 (33%)
CPHXL	NP_001342542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		2/18 (11%)
		HOX	28..82	CDD:197696	18/53 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..363