DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and CPHXL

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001342542.1	Gene:	CPHXL / 105371346	HGNCID:	51815	Length:	405	Species:	Homo sapiens

Alignment Length:	280	Identity:	56/280 - (20%)
Similarity:	101/280 - (36%)	Gaps:	70/280 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 EGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSN 434
            |...:|.:.:...:..::|..||.|.|.||::.|.::.||...||:.||.:.......:..||.|
Human    14 EDHHNEERQTKNKRKTKHRHKFSEELLQELKEIFGENCYPDYTTRKTLAIKFDCPVNVIDNWFQN 78

  Fly   435 RRAKW---RRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPE--SGQQK----- 489
            :||:.   .|.:...|.|:.|.|..:.|       .:|...........|..:  ||.|:
Human    79 KRARLPPAERRRIFVLQKKHDFPVQAHS-------FLSCQETQAAAHNYATKQSLSGAQRALMRR 136

  Fly   490 -------------QPYPYSTSNMCNTSSSSSNSQP------------------CNTIN----PGS 519
                         |...|:..::.|..:.|....|                  |:.:.    |..
Human   137 AGCSHLEKQWIPSQEMGYNCFSLENQETPSQQVGPQCSYLEKPGIPSQQVGSQCSYLEKLGIPSQ 201

  Fly   520 KMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTL-----PMPMTLP---- 575
            :::|::|.:.:... :.|..|:.....|.|.. |..|.::|:..|....     |.|.::|
Human   202 QVASQSSYLVTGTE-KHPGCAMGYGGDTGSGH-SGSGHSTAYHFLSYNSAECLHPPPSSVPYFHG 264

  Fly   576 -------TASAAAFALSFAR 588
                   :..|:.|.|.:|:
Human   265 ERTETKESQHASPFLLDYAQ 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	19/54 (35%)
CPHXL	NP_001342542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		2/18 (11%)
		HOX	28..82	CDD:197696	18/53 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910