Protein Alignment toe and pax5

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: XP_012808654.1
• Gene: pax5 / 100493222
• XenbaseID: XB-GENE-479876
• Length: 388
• Species: Xenopus tropicalis
• Alignment Length: 489
• Identity: 129/489 - (26%)
• Similarity: 192/489 - (39%)
• Gaps: 169/489 - (34%)

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|...  |...            :.|::||:..|:|..|:::.:....|.|||:||...
 Frog    22 LGGVFVNGRPL--PDVV------------RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYY 72

  Fly   169 -----PPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
                 .||:|||||||||||.||.||.:|||:|||:||||||:||:.|.||.|.|.|||||||||
 Frog    73 ETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRI 137

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQ 293
            :|.:..:                 ||:    ...|  |::|.:     ::|    |......::.
 Frog   138 IRTKVQQ-----------------PTN----QQVP--PSNHSI-----VST----GSVTQVSSVS 170

  Fly   294 PGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRS 358
            ...:||||...|.:..  .|||:.|...                          ..|.|.::|..
 Frog   171 TDSAGSSYSISGILGI--TSSNAETNKR--------------------------KRDEGIQESPV 207

  Fly   359 PDADANRMIDIEGEDSESQDSDQPKFRRNR---TTFSPEQLDELEKEFDKSHYPCVNTREK---- 416
            |:..:     :.|.|          |.|.:   ..|:.:|||.|::.|::.||..:.|..:
 Frog   208 PNGHS-----LPGRD----------FLRKQMRGDLFTQQQLDVLDRVFERQHYTDIFTTTEPIKP 257

  Fly   417 -------LAART-ALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTS----SSPTPLVNPVVS 469
                   :|:.| .|.|.:..:                     .|||::    |.|.|...|:|:
 Frog   258 EQTEYSAMASLTGGLDEMKSSL---------------------TSPSSADIGGSVPGPQSYPLVT 301

  Fly   470 --PVSPIPVP-VPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSS------KT 525
              .::...:| .|..||.:||.....|..|..:                 |||..|.      :.
 Frog   302 GRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMV-----------------PGSDFSGSPYSHPQY 349

  Fly   526 SSVSSNQHMEEP---------AAAVATASPTASA 550
            ||.:.:.....|         :||...|.|..:|
 Frog   350 SSYNDSWRFPNPGLLGSPYYYSAARGGAPPATAA 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197	57/100 (57%)
		Homeodomain	385..441	CDD:459649	14/70 (20%)
pax5	XP_012808654.1	PAX	15..139	CDD:128645	63/130 (48%)
		Pax2_C	277..374	CDD:463563	24/134 (18%)