DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and mxtx1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571635.2	Gene:	mxtx1 / 100149566	ZFINID:	ZDB-GENE-000710-7	Length:	309	Species:	Danio rerio

Alignment Length:	304	Identity:	66/304 - (21%)
Similarity:	103/304 - (33%)	Gaps:	123/304 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 IDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVW 431
            ||...:.|.|....:...||.||:||.|.::.|...|:...||.::.||.|:..|.|.|:|:|||
Zfish     7 IDATAKTSGSGAVSRSASRRKRTSFSKEHVELLRATFETDPYPGISLRESLSQTTGLPESRIQVW 71

  Fly   432 FSNRRAK-----------WRR---------------HQRVN------------------LIKQR- 451
            |.||||:           |:.               |::.|                  .||:.
Zfish    72 FQNRRARTLKCKGGKKPLWQTDLPAYNNMQTSPMQIHRKNNESSGATGTLCSPPPAYPDRIKEEM 136

  Fly   452 --------DSPSTSS----------------------SPTPLVNPV-------------VSPVSP 473
                    |:||:.|                      ||:||::|.             .||:|
Zfish   137 EKDAVCGCDTPSSMSISDDSGYCTPSYHQSRAIQSHMSPSPLLSPEHQMPPNWGVRYGRRSPMS- 200

  Fly   474 IPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKT----SSVSSNQHM 534
                         ....|| :..:..||.....|:|:..||:.|.:.::..:    :.:.....:
Zfish   201 -------------SMWSPY-HLEAYACNPGFFYSHSEKHNTLQPLTPVTPDSGCWEAGLDRTSPV 251

  Fly   535 EEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMTLPTAS 578
            :.|..      |.....|..|..:.         |:| .|||.|
Zfish   252 DNPDV------PRTEGQLESGVHHG---------PLP-ELPTLS 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	24/62 (39%)
mxtx1	NP_571635.2	HOX	24..78	CDD:197696	25/53 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810