DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and DUXB

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001338236.1	Gene:	DUXB / 100033411	HGNCID:	33345	Length:	345	Species:	Homo sapiens

Alignment Length:	335	Identity:	71/335 - (21%)
Similarity:	126/335 - (37%)	Gaps:	107/335 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 PDSGSRDSRS-----PDAD----------ANRMIDIE--GEDSESQDSDQ---------PKFRRN 387
            ||..:|:..:     |:::          ..|.:|.:  .|..::|..||         ||..|.
Human    40 PDKAAREQLAKEIGVPESNIQVWFKNYRVKQRKLDYKCFSEKDQTQGHDQSQHLTQEYLPKEARQ 104

  Fly   388 RTTF-SPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRA---KWRRHQRVNLI 448
            :.|| :..|.:.|.:.|:::.:|.:.||:|||.:|.|.|:|:|:||..:|:   |..|.:.:||:
Human   105 KQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLKKSRMEPMNLL 169

  Fly   449 KQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCN 513
            .  |.|:.....|...:|:                     ....|..:|:..:.|.|||..:...
Human   170 V--DDPNERPDATVGWHPI---------------------NLFLPTDSSHYFSCSHSSSGHETLP 211

  Fly   514 TINPGSKMSSKT----SSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMP-MT 573
            .:.|.::.....    .|...|..:.:|..||            ..||.|   ..|:.:|.. :|
Human   212 PVLPSTQAPWDPFRFHVSQGPNVMIMQPTQAV------------QEGEKS---DQPLIIPNHLLT 261

  Fly   574 LPTASAAAFALSFARQYIAKYMGTPLNLGHGSSPIQAQSGRDHQSEER-------------EYED 625
            ||              .:.|.:.||       :|...|...:||:.:.             :.|.
Human   262 LP--------------ILTKDLDTP-------TPFWLQYQEEHQNHKEHSGSGVPQVKSHSQPEP 305

  Fly   626 EQEEEEVINV 635
            |..|::.:|:
Human   306 EHREQQPLNL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/55 (36%)
DUXB	NP_001338236.1	homeodomain	16..72	CDD:238039	4/31 (13%)
		homeodomain	103..161	CDD:238039	21/57 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314		5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910