DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and alx4a

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_001340966.1	Gene:	alx4a / 100006399	ZFINID:	ZDB-GENE-070712-3	Length:	368	Species:	Danio rerio

Alignment Length:	287	Identity:	90/287 - (31%)
Similarity:	132/287 - (45%)	Gaps:	65/287 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 PNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGS-------RDS--RSPDADANRM 366
            |..|:.....::|||....:..|..|.|.....||..|..:|.       :||  :||....:.:
Zfish    95 PPDSSKLQQENSGHNGGLIACYGKDSTGLTDSELPQNSDPAGMDGSYLSVKDSGVKSPQQATSEL 159

  Fly   367 ID----IEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEAR 427
            ..    .|||      |::.|.|||||||:..||:||||.|.|:|||.|..||:||.||.|:|||
Zfish   160 ASPLDKTEGE------SNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEAR 218

  Fly   428 VQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLV----------NPV----VSPVSPIP--- 475
            |||||.|||||||:.:|...::|..:..:::...||:          ||.    .|..||:|
Zfish   219 VQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRPENYAQIQNPSWIGGSSAASPVPGCV 283

  Fly   476 VP---VPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSS-------------- 523
            ||   |...:|       |:|::.|.:.:.....|........:.||...|
Zfish   284 VPCDSVTSCMP-------PHPHAASGVSDFLGVPSPGSHMGQTHMGSLFGSPGMGTGINGYDLNM 341

  Fly   524 ----KTSSVSS-NQHMEEPAAAVATAS 545
                |:||::: ....:|.:||::.|:
Zfish   342 DPDRKSSSIAALRMKAKEHSAAISWAT 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	36/51 (71%)
alx4a	XP_001340966.1	Homeobox	179..231	CDD:278475	36/51 (71%)
alx4a	XP_001340966.1	OAR	344..361	CDD:281777	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910