DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and GLO3

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_011048.1	Gene:	GLO3 / 856859	SGDID:	S000000924	Length:	493	Species:	Saccharomyces cerevisiae

Alignment Length:	530	Identity:	124/530 - (23%)
Similarity:	196/530 - (36%)	Gaps:	158/530 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDI 70
            |::|.|:|....||..||:||..||.|.||.:|:.:|::||..||::|||::||:|.|:|||...
Yeast    15 TQQVFQKLGSNMENRVCFDCGNKNPTWTSVPFGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTIN 79

  Fly    71 ELEKMKAGGNRNAREFL---EDQEDWNE---------RAPITQRYN-------SKAAALYRDKIA 116
            .|.:.|.|||..||:|.   ..::..|.         .:|:.::|.       .|...||..::.
Yeast    80 NLRRFKLGGNHKARDFFLKNNGKQLLNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELV 144

  Fly   117 TLAQGKS-------WDLKEAQGRVGSNNSFSSGGSSNSSYQSRPSATGYGGNGGYQNGGGAEPGG 174
            ...|..|       .|...:..:..|.:.|.|.....||..|.......|......|..|:.|
Yeast   145 LNGQDSSDSPLDTDSDASRSTSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTP-- 207

  Fly   175 YQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQG-GKYAGFGFTREPP-------PKTQSQEL 231
                :|...|       :|..:..|||.:.:..||. .|::....:|:|.       .|:|:::|
Yeast   208 ----KTTVTK-------TRSSILTASRKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDL 261

  Fly   232 FDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVASKVTDMG 296
            ||               ...|.|...||...|. :.:||||::           .|..|:..:..
Yeast   262 FD---------------QFKKEAQQEKEDEFTN-SSSSTKIRQ-----------NDYDSQFMNNS 299

  Fly   297 KRGWNNLAGSNISSPQGGYND---------------------PNF-------------------E 321
            | |.||.:..:|::....:||                     |.|                   :
Yeast   300 K-GNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLTPKFAKLGFGMTMNDANDLAKQQK 363

  Fly   322 DSSAYQRSNSVGGNLAGGLGQQSGVSDSDW---GGWQDNGNSKSH----------MTSSSSYH-- 371
            :|....:.....|.:|...|.|..:|....   |.:.:..|.::|          ..|||||.
Yeast   364 ESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSFDEAANREAHDKLKTFDNATSISSSSYFGE 428

  Fly   372 --------NQLSSSSGGGTASAGLTRDADWSGFEATNYQSSETSYQNASSGGSTARRNMKLQDTS 428
                    |.::||..|    ||        .|:..|..:....: |||:       :.:||...
Yeast   429 DKEVDEFGNPINSSGSG----AG--------NFDGRNSNNGFIDF-NASA-------DDELQMLR 473

  Fly   429 QKLSEGFESL 438
            ..:.:|.|.|
Yeast   474 DVVEQGAEKL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	44/125 (35%)
GLO3	NP_011048.1	COG5347	9..363	CDD:227651	94/388 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810