DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Appl1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_660256.1	Gene:	Appl1 / 72993	MGIID:	1920243	Length:	707	Species:	Mus musculus

Alignment Length:	369	Identity:	74/369 - (20%)
Similarity:	127/369 - (34%)	Gaps:	97/369 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ECSGKHRSLGVHLSFVRSVTMDKWKDIELEKM--------------KAGGNRNAREFLEDQEDWN 94
            |.|..|..|...|:......:.::|:.:|:::              .|..||.:| ..:.:|:..
Mouse    95 ELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAAINRYSR-LSKKRENDK 158

  Fly    95 ERAPITQR-YNSKA----------AAL----YRDKIATLAQGKSWDLKEAQGRVGSNNSFSSGGS 144
            .:..:|:. |.|:.          .||    |:.|||.        |:...|.:.:..||...||
Mouse   159 VKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIAL--------LEPLLGYMQAQISFFKMGS 215

  Fly   145 SNSSYQSRPSATGYGGNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQ 209
            .|.:.|........|.:  .||......|..:..| |..:|          :|.||.|..||...
Mouse   216 ENLNGQLEEFLANIGTS--VQNVRREMDGDVETMQ-QTIED----------LEVASDPLYLPDPD 267

  Fly   210 GGKY---------AGFGFTREPPPK-----------TQSQELFDSTLSTLASGWSLFSTNASKLA 254
            ..|:         ||:...|.....           ||...|.......:|.|.::...|.|.:|
Mouse   268 PTKFPINRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMA 332

  Fly   255 STAKEKAVTTVNLASTKIKEGTLLDSVQ--------CGVTDVASKVTDMGKRGWNNLAGSNISSP 311
            ...:::.. ...:.|...|:.::|.:..        |.:.:: ||...:.:......|..|.|:.
Mouse   333 VDCEDRRY-CFQITSFDGKKSSILQAESKKDHEEWICTINNI-SKQIYLSENPEETAARVNQSAL 395

  Fly   312 QGGYNDPNFEDSSAYQRSNSV--GG---------NLAGGLGQQS 344
            :.....|:|:     ||..|:  ||         :.:|.||.:|
Mouse   396 EAVTPSPSFQ-----QRHESLRPGGQSRPPTARTSSSGSLGSES 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	18/98 (18%)
Appl1	NP_660256.1	Required for RAB5A binding. /evidence=ECO:0000250	1..428		70/361 (19%)
		BAR_APPL1	20..234	CDD:153315	30/149 (20%)
		BAR-PH_APPL	252..376	CDD:270067	24/135 (18%)
		PH	280..375	CDD:278594	15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..433		10/40 (25%)
		F&H. /evidence=ECO:0000250	403..414		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..490
		PTB_APPL	489..624	CDD:269980
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900