DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Arap1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_006508249.1	Gene:	Arap1 / 69710	MGIID:	1916960	Length:	1452	Species:	Mus musculus

Alignment Length:	404	Identity:	87/404 - (21%)
Similarity:	134/404 - (33%)	Gaps:	125/404 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDK--WK 68
            |..|.:.:.....|..|.:||...|.|.|:...:.||..|:|:||.||..:|.|||:.||:  |.
Mouse   536 TSEVAERIWAAAPNRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWT 600

  Fly    69 DIELEKMKAGGNRNAREFLEDQEDWNERAPITQ-----------RYNSKA---AALYR------- 112
            :..::.....||.....|      |....|.::           ||:.:|   ...||
Mouse   601 EALIQLFLHLGNGPGNHF------WAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFG 659

  Fly   113 -----DKIATLAQGKSWDLKEAQGRVGSNNSFSSGGSSNSSYQSRPSATGYGGNGGYQNGGGAEP 172
                 || |..|...:.||.|.|..:|.    .:|.|..|...:.|:....           ||.
Mouse   660 NQEELDK-ALCAAVTTTDLAETQALLGC----GAGVSCFSGDPAAPTPLAL-----------AEQ 708

  Fly   173 GGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPP------------SQGG---KYAGFGFTREP 222
            .|    ||.:.     ||....|.....|.:::.|            |..|   |.|..|   :|
Mouse   709 AG----QTLQM-----EFLRNNQSTEVPRLDSVKPLEKHYSVTLPTVSHSGFLYKTASAG---KP 761

  Fly   223 PPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKI------------KEG 275
            ....:::|.|......|:.|...:..|...:....:.:|...|.||.:.:            .||
Mouse   762 LQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYTEG 826

  Fly   276 TLL------------DSVQC----GVTDVASKV------------------TDMGKRGWNNLAGS 306
            ..|            :.|:|    .|..:|..:                  ....:.||..|.||
Mouse   827 ERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGS 891

  Fly   307 NISS--PQGGYNDP 318
            .:.:  |:|.:.:|
Mouse   892 ELRAVFPEGPWEEP 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	33/134 (25%)
Arap1	XP_006508249.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	331..422	CDD:270073
		PH2_ARAP	438..527	CDD:270074
		ArfGap_ARAP	537..652	CDD:350066	31/120 (26%)
		PH3_ARAP	745..851	CDD:270076	20/108 (19%)
		PH-like	864..954	CDD:388408	8/42 (19%)
		RhoGAP_ARAP	959..1137	CDD:239850
		RA_ARAP1	1173..1265	CDD:340746
		PH5_ARAP	1265..1404	CDD:270079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900