Protein Alignment ArfGAP1 and Arfgap3

DIOPT Version :10

• Sequence 1: NP_524040.2
• Gene: ArfGAP1 / 39417
• FlyBaseID: FBgn0020655
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001344685.1
• Gene: Arfgap3 / 66251
• MGIID: 1913501
• Length: 525
• Species: Mus musculus
• Alignment Length: 549
• Identity: 129/549 - (23%)
• Similarity: 198/549 - (36%)
• Gaps: 142/549 - (25%)

  Fly     1 MASPRTRRVL---QELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSV 62
            |..|..:.:|   :.|:....|..||:||..||.|.|::||:::|::|||.||||||||||:||.
Mouse     1 MGDPSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRST 65

  Fly    63 TMD-KWKDIELEKMKAGGNRNAREFLEDQ----EDWNERAPITQRYNSKAAALYRDKIATLAQGK 122
            .:| .|...:|..|:.|||.||..|....    :|.|      .:|||:||.|||:||.|||
Mouse    66 ELDSNWSWFQLRCMQVGGNSNASSFFHQHGCATKDTN------AKYNSRAAQLYREKIKTLA--- 121

  Fly   123 SWDLKEAQGRVG------------------------SNNSFSSGGSSNSSYQ-SRPSATGYG--- 159
                .:|..|.|                        |:.|....|:..:|.| ...|:|.:|
Mouse   122 ----TQATRRHGTDLWLDSCAAPPVSPPPKEEDFFASHASLEVSGAMQASAQPESASSTPWGLET 182

  Fly   160 ----GNGGYQNGGGAE----PGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKYAGF 216
                ..||...|...|    ||.....:......:|              |.......|.|....
Mouse   183 TPEKHEGGPGQGPSVEGLNTPGKAAPAEVSSIIKKK--------------PNQAKKGLGAKKGSL 233

  Fly   217 G--------FTR-----EPPPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVT----- 263
            |        ||.     :...|.:.||       .||.|.....:..|.|....|:..::
Mouse   234 GAQKLTNTSFTEIEKQAQAVDKRKEQE-------DLARGAPKEESIVSSLRLAYKDLEISRKKDE 291

  Fly   264 TVNLASTKIKE----GTLLDSVQCGVT-DVASKVTDMGKRGWNNLAGSNISSPQGGY-NDPN--- 319
            .:||:..|..|    |....|.:.|:: .|.|.:..:.:.      ...::.|:..| .||.
Mouse   292 RLNLSGQKKVEAERLGMGFGSCRSGISHSVTSDMQTIEQE------SPTLAKPRRKYQEDPEDSY 350

  Fly   320 FEDSSAYQRSNSVGGNLAGGLGQQSGVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTAS 384
            |..||.:...:|     :........:..|.:..|.|..:|.....||......:.|:......|
Mouse   351 FSSSSKWSEQSS-----SRYFDDPMELRSSSFSSWDDGADSYWKKDSSRDPEPAMRSTGSSDRPS 410

  Fly   385 A---------GLTRDAD-------------WSGFEATNYQSSETSYQNASSGGSTARRNMKLQDT 427
            |         |.|.:|.             :.|.:|.....:....:..|:..|.:  :..|.|.
Mouse   411 ARRKPEYEPIGSTDEAQKKFGNVKAISSDMYFGIQAQTDFETRARLERLSTSSSIS--SADLFDE 473

  Fly   428 SQKLSEGFESLDVKSVKPKTATASSANKG 456
            .:|.:.|  :.::.:|.|.....:...:|
Mouse   474 QRKQTAG--NYNLSNVLPNAPDMAQFKQG 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap_ArfGap1	6..121	CDD:350059	54/122 (44%)
Arfgap3	NP_001344685.1	PLN03114	1..>242	CDD:178661	78/267 (29%)
		ArfGap_ArfGap3	4..123	CDD:350085	55/131 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..206		12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..270		6/27 (22%)