Protein Alignment ArfGAP1 and SMAP1

DIOPT Version :9

• Sequence 1: NP_524040.2
• Gene: ArfGAP1 / 39417
• FlyBaseID: FBgn0020655
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001037770.1
• Gene: SMAP1 / 60682
• HGNCID: 19651
• Length: 467
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 110/509 - (21%)
• Similarity: 174/509 - (34%)
• Gaps: 168/509 - (33%)

  Fly     9 VLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELE 73
            :|.:|..:::|..|.:|....|:|.|...|::||:.|:|.||:||||:|.|:||.:|:|...:::
Human    20 ILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQ 84

  Fly    74 KMKAGGNRNAREFLEDQEDWNERAP---------ITQRYNSKAAALYRDKIATLAQGKSWDLKEA 129
            .|:..||..||...|.....|.|.|         |..:|..|.   |.||.|.
Human    85 CMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKK---YYDKNAI------------ 134

  Fly   130 QGRVGSNNSFSSGGSSNSSYQ---SRPSATGYGGNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFF 191
                    :.::..||::..|   |.||.                .....:.:.::.|::|:|..
Human   135 --------AITNISSSDAPLQPLVSSPSL----------------QAAVDKNKLEKEKEKKKEEK 175

  Fly   192 SR-RQVENASRP----------ENLPP--SQGGKYAGFGFTREP--------------------- 222
            .| ::.|..::|          :.|.|  |...|.|.     ||
Human   176 KREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAA-----EPTVDLLGLDGPAVAPVTNGNTT 235

  Fly   223 -PPKTQSQELFD------------------------STLSTLASG-WSLFSTNASKLASTAKEKA 261
             ||.....::|.                        :||||:.|| ..||:...:|....||::.
Human   236 VPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQL 300

  Fly   262 V--TTVNLASTKIKEGTLLDSVQCGVTDVASKVTDMGKRGWNNLAGSNISSPQG----------- 313
            .  :.::|..|...:......|..|.|::  ..|......:.......:..|..
Human   301 SKDSILSLYGTGTIQQQSTPGVFMGPTNI--PFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQS 363

  Fly   314 -----GYNDPNFEDSSAYQ-----RSNSVGGNLAGGLGQQSGVSDSDWGGWQDNGNSKSHMTSSS 368
                 |...||....:|..     ..|.||..  ||:..|.|...|.:|..|    ::....|.|
Human   364 PSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQ--GGMVGQMGAPQSKFGLPQ----AQQPQWSLS 422

  Fly   369 SYHNQLSSSS-GGGTASAGL----TRDADWSGFEATNYQSSETSYQNASSGGST 417
            ..:.|::..| ...|.:||.    :..|.|||                ||.|.|
Human   423 QMNQQMAGMSISSATPTAGFGQPSSTTAGWSG----------------SSSGQT 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	38/113 (34%)
SMAP1	NP_001037770.1	ArfGap	20..120	CDD:279720	34/99 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..224		17/99 (17%)
		Interaction with clathrin heavy chains. /evidence=ECO:0000250	218..222		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..467		17/73 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810