DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP1 and git1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_697386.4	Gene:	git1 / 568935	ZFINID:	ZDB-GENE-100408-5	Length:	761	Species:	Danio rerio

Alignment Length:	512	Identity:	94/512 - (18%)
Similarity:	156/512 - (30%)	Gaps:	154/512 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNAREF 86
            |.:|...:|.|.|:..|:.||.||...|||||.|:|.|:.:....|....|:.::...:..|...
Zfish    11 CADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSI 75

  Fly    87 LED------QEDWNERAPITQ-RYNSKAAALYRDKIATLAQGKSWDLKEAQG------------- 131
            .|.      |.....|.|..| :.:...:...|.|...||.......::..|
Zfish    76 WEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSS 140

  Fly   132 -RVGSNNS----FSSGGSSNSSYQSRPSA-----------------TGYGGNGGYQNGGGAEPGG 174
             |.||..:    .|.|..:|..:..:.:.                 ..||.:.|..:..|..|..
Zfish   141 VRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPID 205

  Fly   175 YQ---------------QYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKYAGFGFTREPPP 224
            |.               ||   |..|:...:...|:          |..:.|.|..........|
Zfish   206 YARQAGHVELAERLVECQY---ELTDRLAFYLCGRR----------PDHKNGHYIIPQMADRARP 257

  Fly   225 KTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVA 289
            |..:|.|                 :.|:||..||:|    :...:.::.|...:|.
Zfish   258 KCPTQSL-----------------DLSELAKAAKKK----LQALNNRLFEELAMDV--------- 292

  Fly   290 SKVTDMGKRGWNNLAGSNISSPQGGYNDPNFEDSSAYQRSNSVGGNLAGGLGQQSGVS----DSD 350
                                     |::.:..::.|...:......|   :.::|.|.    :.:
Zfish   293 -------------------------YDEVDRRENDAVWLTTQNHSTL---VTERSAVPFLPVNPE 329

  Fly   351 WGGWQDNGNSKSHMTSSSSYHN---QLSSSSGGGTASAGLTR----------DADWSGFEATNYQ 402
            :...::.|..|....::..:..   .:.|.:.......|||.          |.|...:::....
Zfish   330 YSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASD 394

  Fly   403 SSETSYQNASSGGSTARRNMKLQDTSQKLSEG----FESLDVKSVKPKTATASSANK 455
            ....|...|.:..:|.|.|......|..||:|    .|.|:||.     |.|||..|
Zfish   395 EDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKK-----ALASSEAK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	27/98 (28%)
git1	XP_697386.4	ArfGap	3..124	CDD:214518	30/112 (27%)
		ANK	<123..220	CDD:238125	13/96 (14%)
		Ank_2	137..229	CDD:289560	15/94 (16%)
		ANK repeat	137..165	CDD:293786	6/27 (22%)
		ANK repeat	167..197	CDD:293786	3/29 (10%)
		GIT_SHD	<281..301	CDD:285690	3/53 (6%)
		GIT_SHD	337..364	CDD:285690	3/26 (12%)
		GIT_CC	416..479	CDD:293167	13/36 (36%)
		GIT1_C	639..754	CDD:289013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900