Protein Alignment ArfGAP1 and APPL2

DIOPT Version :9

• Sequence 1: NP_524040.2
• Gene: ArfGAP1 / 39417
• FlyBaseID: FBgn0020655
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001238833.1
• Gene: APPL2 / 55198
• HGNCID: 18242
• Length: 670
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 55/269 - (20%)
• Similarity: 94/269 - (34%)
• Gaps: 95/269 - (35%)

  Fly   230 ELF----DSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVAS 290
            |:|    ||.||::|   .:..:...:|.:.|::..|:...|.|..       :||....:|||:
Human   222 EMFSKRMDSFLSSVA---DMVQSIQVELEAEAEKMRVSQQELLSVD-------ESVYTPDSDVAA 276

  Fly   291 KVTD---MGKRGWNNLAGSNISSPQGGYNDPNFEDSSAYQRSNSVGGNL--------AGGLGQQS 344
            ...:   :.|.|:.||....      |.....:|....:.:    ||||        ||||.|.
Human   277 PQINRNLIQKAGYLNLRNKT------GLVTTTWERLYFFTQ----GGNLMCQPRGAVAGGLIQD- 330

  Fly   345 GVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDA-------DW--------- 393
                      .||.:..:.......|..|:::.:|    .:|:...|       :|
Human   331 ----------LDNCSVMAVDCEDRRYCFQITTPNG----KSGIILQAESRKENEEWICAINNISR 381

  Fly   394 -----SGFEATNYQSSETSYQ-----------NASSGGSTARRNMKLQDTSQKLSEGFESLDVKS 442
                 ...||...:.::|:.|           ..||..|...:|.::::.:.|
Human   382 QIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDK------------ 434

  Fly   443 VKPKTATAS 451
            :.|| ||||
Human   435 IVPK-ATAS 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720
APPL2	NP_001238833.1	BAR_APPL2	20..240	CDD:153316	7/20 (35%)
		BAR-PH_APPL	258..382	CDD:270067	30/155 (19%)
		PTB_APPL	488..621	CDD:269980
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..670

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900