DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and arfgap3

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001016210.1	Gene:	arfgap3 / 548964	XenbaseID:	XB-GENE-493413	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	514	Identity:	117/514 - (22%)
Similarity:	180/514 - (35%)	Gaps:	166/514 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASPRTR---RVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSV 62
            ||.|..:   .:.:.|:....|..||:||..||.|.|:|||:::|::|||.||||||||||:||.
Frog     1 MAEPHKQDIAAIFRRLRSIPSNKVCFDCGAKNPSWASITYGVFLCIDCSGTHRSLGVHLSFIRST 65

  Fly    63 TMD-KWKDIELEKMKAGGNRNAREFLEDQ----EDWNERAPITQRYNSKAAALYRDKIATLAQGK 122
            .:| .|...:|..|:.|||.||..:....    .|.|      .:|||:|:.|||:::.:.|
Frog    66 ELDSNWSWFQLRCMQVGGNANATVYFRQHGCATNDTN------AKYNSRASQLYRERVKSQA--- 121

  Fly   123 SWDLKEAQGRVGSNNSFSSGGS-------------------SNSSYQSRPSATGYGGN-----GG 163
                .:|..|.|::....:.|:                   .|::.|:.|.|.....|     |.
Frog   122 ----TQATRRHGTDLWIDACGAPPLSPQHQEEDFFAAHSEQDNNTSQAPPQAEDTPINVSSESGP 182

  Fly   164 YQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQ----------------GGK 212
            ..|.|..|.|....|.:...|      .:....||.....|.|..:                |.|
Frog   183 ANNEGEPEVGPSVDYLSVSPK------AALADAENLISAGNAPARESVSVLKKKPGAAKKGLGAK 241

  Fly   213 YAGFGFTREPPPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTL 277
            ..|.|          :|::...:.|.:        ...::.....||:...||    ||..|..:
Frog   242 KGGLG----------AQKVSGKSFSEM--------ERQAQAVDKQKEQEAATV----TKRAEEPV 284

  Fly   278 LDSVQCGVTDV-ASKVTDMGKRGWNNLAGSNISSPQGGYNDPNFEDSSAYQRSNSVGGNLAGGLG 341
            :.|::....|: ..|..|..|  ..||.....:..:                      .|..|.|
Frog   285 VASLRLAYKDLEIQKQKDEEK--LKNLPPKKAAEAE----------------------RLGMGFG 325

  Fly   342 QQSGVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWSGFEATNYQSSET 406
            .:||:|.|          ..|.||:                    :.::|..|......||..|
Frog   326 ARSGISHS----------VLSEMTT--------------------IEQEAPKSVKAKKLYQEEE- 359

  Fly   407 SYQNASSGGSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTATASSANKGTAEDDAWNL 465
                |.....:|.|:...:|..:.::..|.|.|.:|                 ||.|.:
Frog   360 ----AEDFYFSAPRSRYREDPPEPVTSSFLSWDERS-----------------DDYWKM 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	47/114 (41%)
arfgap3	NP_001016210.1	PLN03114	1..498	CDD:178661	117/514 (23%)
arfgap3	NP_001016210.1	ArfGap	10..116	CDD:279720	47/111 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1155557at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010