DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Agfg1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001129068.1	Gene:	Agfg1 / 363266	RGDID:	1560041	Length:	561	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	109/502 - (21%)
Similarity:	183/502 - (36%)	Gaps:	152/502 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLG-VHLSFVRSVTMDKWKDIE 71
            ::|:::.....|.|||:|....|.:|::|.|.::|..|||..|.|. .|.  |:|::|..:...|
  Rat    15 KMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPHR--VKSISMTTFTQQE 77

  Fly    72 LEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAAAL--YRD--KIATLAQ----GKSWDLKE 128
            :|.::..||...::.      |      ...::.:::|:  :||  |:....|    .|.|.:..
  Rat    78 IEFLQKHGNEVCKQI------W------LGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYVPP 130

  Fly   129 AQGRVGSNNSFSSGGSSNSSYQSRP------SATGYGGNGGYQNGG--------GAEPGGYQQYQ 179
            .|.:|.::...|..|||.||..|.|      |..|......:.|.|        |...|  ||.:
  Rat   131 EQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGESAPALHLNKGTPTQSPVVGRSQG--QQQE 193

  Fly   180 TQEF---KDQKEEFFSRRQVENASRPENLPPSQGGKYAGFGFTREPPPKTQSQELFDSTLSTLAS 241
            .::|   .|...:.|:                            .|.|:        ||.:...:
  Rat   194 KKQFDLLSDLGSDIFA----------------------------APAPQ--------STATANFA 222

  Fly   242 GWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVASKVTDMGKRGWNNLAGS 306
            .::.|:::|::.::.|:.........:|                             |.:|..|.
  Rat   223 NFAHFNSHAAQNSANAEFANFDAFGQSS-----------------------------GSSNFGGF 258

  Fly   307 NISSPQGGYNDPNFEDSSAYQRSNSVGGNLAGGLGQQSGVSDSDWGGWQDNGNSKSHMTSSSSYH 371
            ..:|     :.| |:..:....:.||..|.| ........|.:|:|.:   ..|:||.|:|:.
  Rat   259 PTAS-----HSP-FQPQTTGGSAGSVNANFA-HFDNFPKSSSADFGSF---STSQSHQTASTV-- 311

  Fly   372 NQLSSSSGG-GTA-------------SAGLTRDADWSGFEATNYQS-----SETSYQNASSG--- 414
            :::|::..| .||             |||...| ..|||..|....     |..|:.:|||.
  Rat   312 SKVSTNKAGLQTADKYAALANLDNIFSAGQGGD-QGSGFGTTGKAPVGSVVSVPSHSSASSDKYA 375

  Fly   415 ---------GSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTATASS 452
                     .|.|..|.....||...|..|.::.| ...|:|..|||
  Rat   376 ALAELDSVFSSAATSNNAYTSTSNASSSVFGTVPV-GASPQTQPASS 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	28/110 (25%)
Agfg1	NP_001129068.1	COG5347	8..309	CDD:227651	78/384 (20%)
		ArfGap	14..135	CDD:214518	33/133 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..193		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..451		6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810