DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP1 and Appl2

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001102211.1	Gene:	Appl2 / 362860	RGDID:	1563028	Length:	662	Species:	Rattus norvegicus

Alignment Length:	231	Identity:	46/231 - (19%)
Similarity:	80/231 - (34%)	Gaps:	55/231 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 ELFDSTL-STLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVASKVT 293
            |:|..:: ..|:|...:..:...:|.:.|.:..|:...|.|..       :||.....|||:...
  Rat   216 EMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLSVS-------ESVYTPDIDVATPQI 273

  Fly   294 D---MGKRGWNNLAGSNISSPQGGYNDPNFEDSSAYQRSNSVGGNL--------AGGLGQQSGVS 347
            :   :.|.|:.||....      |.....:|....:.:    ||||        ||||.|.
  Rat   274 NRNLIQKTGYLNLRNKT------GLVTTTWERLYFFTQ----GGNLMCQPRGAVAGGLIQD---- 324

  Fly   348 DSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWSGFEATNYQSSETSYQNAS 412
                   .||.:..:.......|..|:|:.||    ..|:...|:           |...|:...
  Rat   325 -------LDNCSVMAVDCEDRRYCFQISTPSG----KPGIILQAE-----------SRKEYEEWI 367

  Fly   413 SGGSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTA 448
            ...:...|.:.|.|..:.::.......:::|.|.|:
  Rat   368 CAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316	4/17 (24%)
		BAR-PH_APPL	252..376	CDD:270067	33/166 (20%)
		PTB_APPL	480..613	CDD:269980
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900