DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Agap3

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_006236000.1	Gene:	Agap3 / 362300	RGDID:	1310751	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	168	Identity:	47/168 - (27%)
Similarity:	65/168 - (38%)	Gaps:	42/168 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASPRTRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMD 65
            :.:..|...:|.::....||.|.:|...||.|.|:..|..:|:||||.||.||.|||.|||:.:|
  Rat   838 LGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 902

  Fly    66 KWKDIELEKMKAGGNRNAREF----------------LEDQEDWNERAPITQRYNSK-------- 106
            .|....|..|.|.||..|...                .|::|.|     |..:|..|
  Rat   903 DWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERW-----IRAKYEQKLFLAPLPS 962

  Fly   107 ---------AAALYRDK----IATLAQGKSWDLKEAQG 131
                     ..|:..|.    :..||.|...::.|..|
  Rat   963 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYG 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	40/139 (29%)
Agap3	XP_006236000.1	small_GTPase	309..474	CDD:197466
		Centaurin_gamma	311..468	CDD:133303
		PH_AGAP	584..827	CDD:241281
		PH	587..>648	CDD:278594
		ArfGap	855..960	CDD:279720	38/109 (35%)
		Ank_2	971..1061	CDD:289560	7/30 (23%)
		ANK	971..>1060	CDD:238125	7/30 (23%)
		ANK repeat	971..1001	CDD:293786	7/30 (23%)
		ANK repeat	1003..1034	CDD:293786
		ANK repeat	1036..1061	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900