DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and CenG1A

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_723849.1	Gene:	CenG1A / 34803	FlyBaseID:	FBgn0028509	Length:	995	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	85/360 - (23%)
Similarity:	121/360 - (33%)	Gaps:	147/360 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNA 83
            |..|.:||..||:|.|:..|:.:|:||||.||:||.|:|.|||:.:|.|....|..|.|.||..|
  Fly   714 NGFCVDCGAPNPEWASLNLGVLMCIECSGVHRNLGSHISKVRSLGLDDWPSPHLSVMLAIGNSLA 778

  Fly    84 REFLEDQEDWNERAPITQRYNSKAAALYRDKIATLAQGKSWDLKEAQGRVGSNNSFSSGGSSNSS 148
            ....|.    |.|    ||....:.|...||       :.|                    ..|.
  Fly   779 NSVWES----NTR----QRVKPTSQASREDK-------ERW--------------------VRSK 808

  Fly   149 YQSRPSATGYGGNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKY 213
            |:::...|..|      ||..|.|.                                 ||.|
  Fly   809 YEAKEFLTPLG------NGSSAHPS---------------------------------PSPG--- 831

  Fly   214 AGFGFTREPPPKTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLL 278
                           |:|.::.:.      :...:..|.||:...|  ||..|:::..::...||
  Fly   832 ---------------QQLIEAVIR------ADIKSIVSILANCPSE--VTNANVSARDVRTPLLL 873

  Fly   279 DSVQCGVTDVA-----------SKVTD-MGK------RGWNNL-------------AGSNISSP- 311
               .|.:.::|           .|.|| .|:      |...:|             ||:.|.:|
  Fly   874 ---ACAIGNLAIAQLLIWNGANIKHTDHEGRTCLAYARAAQSLATAKSIKAAAAAQAGTTIPAPA 935

  Fly   312 ---QGGYNDP--NFEDSSAYQRSNSVGGNLAGGLG 341
               .||...|  |.||::|..       .|..|||
  Fly   936 PPTNGGIPAPQYNVEDTTALV-------ELLEGLG 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	37/94 (39%)
CenG1A	NP_723849.1	SelP_N	<5..41	CDD:282453
		Centaurin_gamma	143..300	CDD:133303
		RAS	144..295	CDD:214541
		PH_AGAP	451..686	CDD:241281
		PH	454..>521	CDD:278594
		ArfGap	702..818	CDD:279720	43/138 (31%)
		ANK	<834..907	CDD:238125	16/83 (19%)
		ANK repeat	834..866	CDD:293786	8/39 (21%)
		Ank_5	859..907	CDD:290568	9/50 (18%)
		ANK repeat	868..897	CDD:293786	5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740