DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Git1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001004144.1	Gene:	Git1 / 216963	MGIID:	1927140	Length:	770	Species:	Mus musculus

Alignment Length:	515	Identity:	95/515 - (18%)
Similarity:	159/515 - (30%)	Gaps:	158/515 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNAREF 86
            |.:|...:|.|.|::.|:.:|.||...|||||.|:|.|:.:....|....|:.:....:..|...
Mouse    11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSI 75

  Fly    87 LEDQ-------EDWNERAPITQRYNSKAAALYRDKIATLAQGKSWDLKEAQG------------- 131
            .|..       :....:|....:.:...:...|.|...||.......::..|
Mouse    76 WEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSS 140

  Fly   132 -RVGSNNS----FSSGGSSNSSYQSRPSA-----------------TGYGGNGGYQNGGGAEPGG 174
             |.|:..:    .|.|..:|..:..:.:.                 ..||.:.|..:..|..|..
Mouse   141 VRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPID 205

  Fly   175 YQ---------------QYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGGKYAGFGFTREPPP 224
            |.               ||   |..|:...:...|:          |..:.|.|...........
Mouse   206 YARQAGHHELAERLVECQY---ELTDRLAFYLCGRK----------PDHKNGHYIIPQMADRSRQ 257

  Fly   225 KTQSQELFDSTLSTLASGWSLFSTNASKLASTAKEKAVTTVNLASTKIKEGTLLDSVQCGVTDVA 289
            |..||.|                 :.|:||..||:|    :...|.::.|            ::|
Mouse   258 KCMSQSL-----------------DLSELAKAAKKK----LQALSNRLFE------------ELA 289

  Fly   290 SKVTDMGKRGWNN---LAGSNIS--------------SPQGGYNDPNFEDSSAYQRSNS------ 331
            ..|.|...|..|:   ||..|.|              :|:  |:....:......|.|:
Mouse   290 MDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPE--YSATRNQGRQKLARFNAREFATL 352

  Fly   332 VGGNLAGGLGQQSGVS-DSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWSG 395
            :...|:....:|.|.| .|.....:.:..|:|.:.....|.:..|
Mouse   353 IIDILSEAKRRQQGKSLSSPTDNLELSARSQSELDDQHDYDSVAS-------------------- 397

  Fly   396 FEATNYQSSETSYQNASSGGSTARRNMKLQDTSQKLSEGFESLDVKSVKPKTATASSANK 455
                   ..:|..:...|.|:|.....:..|:|. ||:|..:|. :.::.|.|.|:|..|
Mouse   398 -------DEDTDQEPLPSAGATRNNRARSMDSSD-LSDGAVTLQ-EYLELKKALATSEAK 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	23/98 (23%)
Git1	NP_001004144.1	Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	1..124		26/112 (23%)
		ArfGap_GIT1	1..111	CDD:350071	23/99 (23%)
		ANK 1	132..161		4/28 (14%)
		Ank_2	137..229	CDD:372319	14/94 (15%)
		ANK repeat	137..165	CDD:293786	5/27 (19%)
		ANK 2	166..195		2/28 (7%)
		ANK repeat	167..197	CDD:293786	3/29 (10%)
		ANK 3	199..228		6/31 (19%)
		Interaction with PCLO. /evidence=ECO:0000250\|UniProtKB:Q9Z272	245..374		31/163 (19%)
		Interaction with PTK2/FAK1. /evidence=ECO:0000250\|UniProtKB:Q9Z272	253..424		39/232 (17%)
		Interaction with ARHGEF7. /evidence=ECO:0000250\|UniProtKB:Q9Z272	254..376		30/156 (19%)
		GIT_SHD	<281..301	CDD:369921	6/31 (19%)
		GIT_SHD	337..365	CDD:369921	3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..425		14/89 (16%)
		Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250\|UniProtKB:Q9Z272	375..596		19/103 (18%)
		Required for localization at synapses. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	375..596		19/103 (18%)
		GIT_CC	418..482	CDD:374629	11/33 (33%)
		Interaction with MAPK1. /evidence=ECO:0000269\|PubMed:15923189	420..475		11/31 (35%)
		Interaction with IKBKG. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	429..629		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..615
		Interaction with PXN and TGFB1I1. /evidence=ECO:0000250\|UniProtKB:Q9Z272	646..770
		GIT1_C	649..763	CDD:371961
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900