DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Acap1

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_722483.2	Gene:	Acap1 / 216859	MGIID:	2388270	Length:	740	Species:	Mus musculus

Alignment Length:	148	Identity:	39/148 - (26%)
Similarity:	67/148 - (45%)	Gaps:	43/148 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKD--- 69
            :|..:::..|.|::|.:|....|:|.|:..|:.:|::|||.|||||||.|.|||:|:|.|:.
Mouse   406 QVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELV 470

  Fly    70 ------------------IELEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAAALYRDKIA 116
                              :|...:|..|...:|   :::|.|.....:.:::.:|
Mouse   471 KLMCELGNVIINQIYEARVEAMAVKKPGPSCSR---QEKEAWIHAKYVEKKFLTK---------- 522

  Fly   117 TLAQGKSWDLKEAQGRVG 134
                     |.|.:||.|
Mouse   523 ---------LPEIRGRRG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	34/126 (27%)
Acap1	NP_722483.2	Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250\|UniProtKB:Q15027	1..382
		BAR_ACAP1	18..217	CDD:153323
		PH	266..360	CDD:278594
		PH_ACAP	268..364	CDD:270070
		Required for interaction with GULP1. /evidence=ECO:0000250\|UniProtKB:Q15027	405..740		39/148 (26%)
		ArfGap	406..519	CDD:279720	33/115 (29%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250	525..566		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..562		4/7 (57%)
		Ank_2	575..670	CDD:289560
		ANK repeat	575..602	CDD:293786
		ANK	<592..692	CDD:238125
		ANK repeat	606..637	CDD:293786
		ANK repeat	639..670	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900