DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and Acap3

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_997106.1	Gene:	Acap3 / 140500	MGIID:	2153589	Length:	833	Species:	Mus musculus

Alignment Length:	299	Identity:	74/299 - (24%)
Similarity:	115/299 - (38%)	Gaps:	94/299 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASPRT----------------RRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHR 50
            |||.|                ..|||.::....||:|.:||..:|:|.|:..|:.:|:||||.||
Mouse   382 ASPSTSSIDSTTDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHR 446

  Fly    51 SLGVHLSFVRSVTMDKWKDIELEKMKAGGNRNAREFLE------------------DQEDWNE-- 95
            |||||.|.|||:|:|.|:...|:.|...||....:..|                  |:|.|.:
Mouse   447 SLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGPGVRKPTASSSRQDKEAWIKDK 511

  Fly    96 ----------------------RAPITQR-YNSKAAALYRDK---------IATLAQGKSWDLKE 128
                                  ||...|| ::|..|...|.|         :|.|:...:.:.|.
Mouse   512 YVEKKFLRKLTSAPAREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAATMERKF 576

  Fly   129 AQ------GRVGSNNSFSSGGSSNSSYQSRPSATGYGGNGGYQN-----GGGA------EPGGYQ 176
            .:      ..:.|..|:...|::.:..:|..|.:|.||:....:     |.|:      |..|.:
Mouse   577 RRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGTGSVVDSVTEEEGAE 641

  Fly   177 QYQTQEFKDQKEEFFSRRQV---------ENASRPENLP 206
            ..::....|.:.|.:|...|         ..|:|..:||
Mouse   642 SEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLP 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	46/149 (31%)
Acap3	NP_997106.1	BAR_ACAP3	16..215	CDD:153321
		PH	269..363	CDD:278594
		PH_ACAP	271..367	CDD:270070
		ArfGap	403..521	CDD:279720	39/117 (33%)
		ANK	671..786	CDD:238125	4/10 (40%)
		Ank_2	671..764	CDD:289560	4/10 (40%)
		ANK repeat	700..731	CDD:293786
		ANK repeat	733..764	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900