DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP1 and AGAP3

DIOPT Version :9

Sequence 1:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_114152.3	Gene:	AGAP3 / 116988	HGNCID:	16923	Length:	911	Species:	Homo sapiens

Alignment Length:	159	Identity:	46/159 - (28%)
Similarity:	62/159 - (38%)	Gaps:	42/159 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDKWKDIELEK 74
            :|.::....||.|.:|...||.|.|:..|..:|:||||.||.||.|||.|||:.:|.|....|..
Human   665 VQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAV 729

  Fly    75 MKAGGNRNAREF----------------LEDQEDWNERAPITQRYNSK----------------- 106
            |.|.||..|...                .|::|.|     |..:|..|
Human   730 MTAMGNALANSVWEGALGGYSKPGPDACREEKERW-----IRAKYEQKLFLAPLPSSDVPLGQQL 789

  Fly   107 AAALYRDK----IATLAQGKSWDLKEAQG 131
            ..|:..|.    :..||.|...::.|..|
Human   790 LRAVVEDDLRLLVMLLAHGSKEEVNETYG 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	40/136 (29%)
AGAP3	NP_114152.3	small_GTPase	126..291	CDD:197466
		Centaurin_gamma	128..285	CDD:133303
		PH_AGAP	401..645	CDD:241281
		PH	404..>465	CDD:278594
		ArfGap	664..778	CDD:279720	39/117 (33%)
		Ank_2	789..879	CDD:289560	7/30 (23%)
		ANK	789..>878	CDD:238125	7/30 (23%)
		ANK repeat	789..819	CDD:293786	7/30 (23%)
		ANK repeat	821..852	CDD:293786
		ANK repeat	854..879	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810