DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP1 and ARAP1

DIOPT Version :9

Sequence 1:NP_524040.2 Gene:ArfGAP1 / 39417 FlyBaseID:FBgn0020655 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_001035207.1 Gene:ARAP1 / 116985 HGNCID:16925 Length:1450 Species:Homo sapiens


Alignment Length:570 Identity:113/570 - (19%)
Similarity:165/570 - (28%) Gaps:214/570 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSFVRSVTMDK--WK 68
            |..|.:.:.....|..|.:||...|.|.|:...:.||..|:|:||.||..:|.|||:.||:  |.
Human   534 TSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWT 598

  Fly    69 DIELEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAA---------ALYR------------ 112
            :..:|.....||.....|      |....|.::.....::         |.||            
Human   599 ETLIELFLQLGNGAGNRF------WAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFG 657

  Fly   113 -----DKIATLAQGKSWDLKEAQGRVGSN---NSFSSGGSSNSSYQSRPSATGYGGNGGYQNGGG 169
                 || |..|...:.||.|.|..:|..   |.||....:.:     |.|.             
Human   658 NQEELDK-ALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPT-----PLAL------------- 703

  Fly   170 AEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPP------------SQGG---KYAGFG-- 217
            ||..|    ||.:.     ||....:.....|.:::.|            |..|   |.|..|  
Human   704 AEQAG----QTLQM-----EFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL 759

  Fly   218 ---------FTRE----------------------------------PPPKTQSQELFDSTLSTL 239
                     |:|.                                  |||.|..   |:.|....
Human   760 LQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHG---FEHTFEVY 821

  Fly   240 ASGWSLFSTNASKLASTAKE--KAVTTV---------------NLASTKIKEGTLLDSVQCGVTD 287
            ..|..|:...... |..|.|  |.:...               .|.....|.|..|...|     
Human   822 TEGERLYLFGLES-AEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQ----- 880

  Fly   288 VASKVTDMGKRGWNNLAGSNISS--PQGGYNDP----NFEDSSAYQRSNSVGGNLAGGLGQQ--- 343
                      .||.:|:||.:.:  |:|...:|    ..::.|           :.|....|   
Human   881 ----------EGWFSLSGSELRAVFPEGPCEEPLQLRKLQELS-----------IQGDSENQVLV 924

  Fly   344 ----------SGVSDSDWGGWQDNGNSKSHMTSSSSYHNQLSSSSGGGTASAGLTRDADWS--GF 396
                      .|....|:.||..              ..|.:::|.|.|.|.....|:|..  .:
Human   925 LVERRRTLYIQGERRLDFMGWLG--------------AIQKAAASMGDTLSEQQLGDSDIPVIVY 975

  Fly   397 EATNY-----QSSETSYQNASSGGSTAR--RNMKLQDTSQKLSEGFESLD 439
            ...:|     .:||..|:.......|.|  .:::....|..|.||.:.:|
Human   976 RCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP1NP_524040.2 ArfGap 7..114 CDD:279720 32/134 (24%)
ARAP1NP_001035207.1 SAM_Arap1,2,3 6..68 CDD:188889
SAM 10..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..144
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..302
PH 328..419 CDD:278594
PH1_ARAP 329..421 CDD:270073
PH2_ARAP 436..525 CDD:270074
ArfGap 535..651 CDD:279720 32/121 (26%)
PH3_ARAP 743..849 CDD:270076 19/109 (17%)
PH 744..848 CDD:278594 19/107 (18%)
PH4_ARAP 862..952 CDD:270077 21/129 (16%)
RhoGAP_ARAP 956..1135 CDD:239850 16/70 (23%)
RA 1172..1261 CDD:279168
PH5_ARAP 1263..1402 CDD:270079
PH 1299..1391 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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