DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and MRX21

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_015336.1	Gene:	MRX21 / 856121	SGDID:	S000006215	Length:	326	Species:	Saccharomyces cerevisiae

Alignment Length:	340	Identity:	106/340 - (31%)
Similarity:	174/340 - (51%)	Gaps:	57/340 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 LDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQ----RMGIS 323
            |.:.|..|...||.:::....     .:|||:|||||||..:|.:|:|:.||||:.    ..||.
Yeast     5 LTVLEQPNSIKDFLKQDSNIA-----FLAGGVAGAVSRTVVSPFERVKILLQVQSSTTSYNRGIF 64

  Fly   324 ECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRL---IRGDDGSRQMSIVERFYAG 385
            ..:..:.:|.|::.::||||:|.::|.|.:|.:|..||..|:.   :.|::|..|::..:|.::|
Yeast    65 SSIRQVYHEEGTKGLFRGNGLNCIRIFPYSAVQFVVYEACKKKLFHVNGNNGQEQLTNTQRLFSG 129

  Fly   386 AAAGGISQTIIYPMEVLKTRLAL-------------RRTGQYAGIADAAVKIYKQE-GVRSFYRG 436
            |..||.|....||::::||||::             :...:..||.....:.|:.| |:|..|||
Yeast   130 ALCGGCSVVATYPLDLIKTRLSIQTANLSSLNRSKAKSISKPPGIWQLLSETYRLEGGLRGLYRG 194

  Fly   437 YVPNILGILPYAGIDLAVYETLKRRYIANHDNNEQPSF---LVLLACGSTSSTLGQLCSYPLALV 498
            ..|..||::||..::.||||.|  |....:.::.|||:   |..|..|:.|..:.|..:||..|:
Yeast   195 VWPTSLGVVPYVALNFAVYEQL--REFGVNSSDAQPSWKSNLYKLTIGAISGGVAQTITYPFDLL 257

  Fly   499 RTRLQAQAAETIANQKRKTQIPLKSSDAHSGEE---TMTGLFRKIV---RQEGLTGLYRGITPNF 557
            |.|.|..|.                    .|.|   ..|.::..:|   |.||::|.|:|:..|.
Yeast   258 RRRFQVLAM--------------------GGNELGFRYTSVWDALVTIGRAEGVSGYYKGLAANL 302

  Fly   558 LKVLPAVSISYVVYE 572
            .||:|:.::|::|||
Yeast   303 FKVVPSTAVSWLVYE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455
		EFh	116..176	CDD:238008
		EFh	186..242	CDD:238008
		Mito_carr	285..370	CDD:278578	33/91 (36%)
		Mito_carr	375..463	CDD:278578	33/101 (33%)
		Mito_carr	470..581	CDD:278578	33/112 (29%)
MRX21	NP_015336.1	PTZ00169	26..304	CDD:240302	94/299 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I2282
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1061
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99042
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
TreeFam	0	0.000	Not matched by this tool.
	6	5.990