DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and SAL1

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_014316.3	Gene:	SAL1 / 855641	SGDID:	S000005027	Length:	494	Species:	Saccharomyces cerevisiae

Alignment Length:	374	Identity:	90/374 - (24%)
Similarity:	166/374 - (44%)	Gaps:	87/374 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DEERLER---IFNKLDRDGDGRIDIHDLSAAL----HEFGLSSVYAEKFLQQSDKDQSGNVGFAE 170
            |::|..|   :|.:||..|:|::.:.:|.:|.    |....:....:......|.::...|..::
Yeast     9 DKQRDIRYACLFKELDVKGNGQVTLDNLISAFEKNDHPLKGNDEAIKMLFTAMDVNKDSVVDLSD 73

  Fly   171 FLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDL-GLDIDMDEARNLLT--RMDK----- 227
            |..|....|..:...|..:|.:.|||:.:.|:.....|| ...|..:|..:.|:  :|:|
Yeast    74 FKKYASNAESQIWNGFQRIDLDHDGKIGINEINRYLSDLDNQSICNNELNHELSNEKMNKFSRFF 138

  Fly   228 --------------------------------DGSLNISFNEWRDFMLLAP---STDIHDLIK-F 256
                                            |..|.:::::||||:||.|   .:.:|.... |
Yeast   139 EWAFPKRKANIALRGQASHKKNTDNDRSKKTTDSDLYVTYDQWRDFLLLVPRKQGSRLHTAYSYF 203

  Fly   257 WRHSTYLDIGE--DMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQR 319
            :..:..:|:..  |:.:.:||.:       .:...:||||:|.:|||||||.||:||:|..:|..
Yeast   204 YLFNEDVDLSSEGDVTLINDFIR-------GFGFFIAGGISGVISRTCTAPFDRLKVFLIARTDL 261

  Fly   320 MGI------------------------SECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAY 360
            ..|                        ::.:..:..:||.::.:.|||:||:|:.||::.||.::
Yeast   262 SSILLNSKTDLLAKNPNADINKISSPLAKAVKSLYRQGGIKAFYVGNGLNVIKVFPESSIKFGSF 326

  Fly   361 EQMKRLIRGDDGSRQMSIVERF---YAGAAAGGISQTIIYPMEVLKTRL 406
            |..|:::...:|.|....:.:|   .||..||..:|..:||::.||.|:
Yeast   327 EVTKKIMTKLEGCRDTKDLSKFSTYIAGGLAGMAAQFSVYPIDTLKFRV 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	38/183 (21%)
		EFh	116..176	CDD:238008	14/66 (21%)
		EFh	186..242	CDD:238008	18/95 (19%)
		Mito_carr	285..370	CDD:278578	33/108 (31%)
		Mito_carr	375..463	CDD:278578	11/35 (31%)
		Mito_carr	470..581	CDD:278578
SAL1	NP_014316.3	EF-hand_7	19..77	CDD:290234	11/57 (19%)
		EFh	20..76	CDD:298682	11/55 (20%)
		EF-hand_7	54..109	CDD:290234	11/54 (20%)
		Dockerin_like	62..109	CDD:277547	11/46 (24%)
		Mito_carr	231..335	CDD:278578	33/103 (32%)
		Mito_carr	343..>402	CDD:278578	11/33 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1460
OMA	1	1.010	-	-		QHG55854
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24089
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X287
TreeFam	1	0.960	-	-
	9	8.760