Protein Alignment SCaMC and SLC25A23

DIOPT Version :9

• Sequence 1: NP_729802.1
• Gene: SCaMC / 39415
• FlyBaseID: FBgn0052103
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_011526576.1
• Gene: SLC25A23 / 79085
• HGNCID: 19375
• Length: 624
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 248/533 - (46%)
• Similarity: 330/533 - (61%)
• Gaps: 93/533 - (17%)

  Fly   112 EDEERLERIFNKLDRDGDGRIDIHDLSAALHEF-----------GLSSVYAEKFLQQSDKDQSGN 165
            |..:|..|:|.:||.:.|||:|:|:|...|...           |:||        :.|.|..|.
Human     9 ERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISS--------EGDADPDGG 65

  Fly   166 VGFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGS 230
            :...||..|::|.|:.|:|.|..||:|:||.:|:.|:..:|:.||:.|.:::|..:|..||:||:
Human    66 LDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGT 130

  Fly   231 LNISFNEWRDFMLLAPSTDIHDLIKFWRHST---------------------------------- 261
            :.|.:.||||..||....::.|::.||:|||
Human   131 MTIDWQEWRDHFLLHSLENVEDVLYFWKHSTLSSAGFSAWIKDSTAEQNRSKTTVLARRSGSHLK 195

  Fly   262 -------------YLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYL 313
                         .|||||.:.|||:|:::|..||:||:.||||.:|||||||.||||||:||::
Human   196 SQHFGRPKWADHEVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFM 260

  Fly   314 QV---QTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDGSRQ 375
            ||   :|.|:.|...:..|:.|||.||:||||||||||||||:|.||.||||:||.|.|.  ...
Human   261 QVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQ--QET 323

  Fly   376 MSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYKQEGVRSFYRGYVPN 440
            :.:.|||.||:.||..:||||||||||||||.|||||||.|:.|.|.:|.::||.|:|||||:||
Human   324 LHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPN 388

  Fly   441 ILGILPYAGIDLAVYETLKRRYIA--NHDNNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTRLQ 503
            :|||:||||||||||||||..::.  :||:.: |..|||||||:.|||.||:.||||||||||:|
Human   389 VLGIIPYAGIDLAVYETLKNWWLQQYSHDSAD-PGILVLLACGTISSTCGQIASYPLALVRTRMQ 452

  Fly   504 AQAAETIANQKRKTQIPLKSSDAHSGEE-TMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSIS 567
            |||:                  ...|.: :|.||.|.|:.|||:.||||||.|||:||:||||||
Human   453 AQAS------------------IEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSIS 499

  Fly   568 YVVYEYTSRALGI 580
            |||||...:|||:
Human   500 YVVYENMKQALGV 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	51/145 (35%)
		EFh	116..176	CDD:238008	21/70 (30%)
		EFh	186..242	CDD:238008	23/55 (42%)
		Mito_carr	285..370	CDD:278578	56/87 (64%)
		Mito_carr	375..463	CDD:278578	59/87 (68%)
		Mito_carr	470..581	CDD:278578	61/112 (54%)
SLC25A23	XP_011526576.1	EF-hand_7	16..75	CDD:290234	19/66 (29%)
		EFh	18..76	CDD:238008	19/65 (29%)
		EFh	85..142	CDD:238008	23/56 (41%)
		EF-hand_7	85..137	CDD:290234	19/51 (37%)
		Mito_carr	232..319	CDD:278578	56/86 (65%)
		PTZ00169	237..510	CDD:240302	173/293 (59%)
		Mito_carr	322..411	CDD:278578	59/88 (67%)
		Mito_carr	420..511	CDD:278578	59/109 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5408
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1481
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm40414
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770