DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCaMC and Slc25a54

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_083330.1	Gene:	Slc25a54 / 74686	MGIID:	1921936	Length:	473	Species:	Mus musculus

Alignment Length:	489	Identity:	211/489 - (43%)
Similarity:	313/489 - (64%)	Gaps:	37/489 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 ILPTEIPIEDEERL--ERIFNKLDRDGDGRIDIHDLSAALHEFGLSSVYAE----KFLQQSDKDQ 162
            :||:|....|..||  |.:|..||.:|||.:||.:|...|..:  :|.::|    :....:|.:.
Mouse     9 LLPSEACQNDYNRLAYEVLFEDLDHNGDGVVDITELRDGLKHW--NSSFSEDTEKEIFMDADSNA 71

  Fly   163 SGNVGFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDK 227
            ...:.|.||:.|:::|||.:.|.|..||||.||.:|..|:::|.:.||:.|.:.:|:::|..||.
Mouse    72 DSGLDFEEFVQYLQDHEKKMKLAFKSLDKNDDGVIDASEIVAAVRSLGIHISLSQAKDILKSMDF 136

  Fly   228 DGSLNISFNEWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAG 292
            |||:.:.::|||||....|:.:|.|:::||:|||.:||||.:::||:||::|..:|.||:.|||.
Mouse   137 DGSMTVDWDEWRDFFFFHPAKNITDIVRFWKHSTIIDIGESISIPDEFTEQEKMSGEWWKRLVAA 201

  Fly   293 GIAGAVSRTCTAPLDRIKVYLQVQT---QRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETA 354
            |||.|::|||||||:|:||.:|||:   .:||:......|:.|||..|:|||||:|:||||||||
Mouse   202 GIASAITRTCTAPLERLKVTMQVQSLKVNKMGLVHMFKQMVKEGGFFSLWRGNGVNILKIAPETA 266

  Fly   355 FKFAAYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIAD 419
            .|..||||.|:|:..|  ...:.:::||.||..||..|||.:|||||:||||.|.:||:|:|:.|
Mouse   267 IKIGAYEQYKKLLSFD--GDHLGVLQRFTAGCMAGATSQTCVYPMEVIKTRLNLSKTGEYSGLVD 329

  Fly   420 AAVKIYKQEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANH-DNNEQPSFLVLLACGST 483
            ...|:.|:||:::|.:|||||:|.|:||||:||.::|.||..::.:: .|:..|...::|.|.:.
Mouse   330 CVRKLLKREGIQAFSKGYVPNLLSIIPYAGLDLTIFELLKNHWLEHYAGNSVNPGIAIVLGCSTV 394

  Fly   484 SSTLGQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEET--MTGLFRKIVRQEGL 546
            |.|.|||.|:||.|||||:||...|                     :||  |..|.::|..:||.
Mouse   395 SHTCGQLASFPLILVRTRMQAVMLE---------------------KETVRMMQLIQEIYTKEGK 438

  Fly   547 TGLYRGITPNFLKVLPAVSISYVVYEYTSRALGI 580
            .|.:||.|||.||:||||.|..|.:|...|..|:
Mouse   439 KGFFRGFTPNVLKLLPAVGIGSVAHELVKRLFGL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	53/148 (36%)
		EFh	116..176	CDD:238008	20/65 (31%)
		EFh	186..242	CDD:238008	24/55 (44%)
		Mito_carr	285..370	CDD:278578	50/87 (57%)
		Mito_carr	375..463	CDD:278578	45/87 (52%)
		Mito_carr	470..581	CDD:278578	43/113 (38%)
Slc25a54	NP_083330.1	FRQ1	1..152	CDD:227455	53/144 (37%)
		EFh	28..85	CDD:238008	17/58 (29%)
		EFh	90..151	CDD:238008	25/60 (42%)
		Mito_carr	194..283	CDD:278578	51/90 (57%)
		Mito_carr	284..376	CDD:278578	45/91 (49%)
		Mito_carr	389..471	CDD:278578	41/102 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm42487
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.790