DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and Slc25a54

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001103110.1	Gene:	Slc25a54 / 691448	RGDID:	1583925	Length:	473	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	209/485 - (43%)
Similarity:	315/485 - (64%)	Gaps:	33/485 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PTEIPIEDEERL--ERIFNKLDRDGDGRIDIHDLSAALH----EFGLSSVYAEKFLQQSDKDQSG 164
            |::.|..|.:.|  |.:|..|||:|||.:||.:|...|.    .||:..  .:|.|:.:|.:...
  Rat    11 PSKAPKSDYDDLAFEILFEDLDRNGDGVVDITELRDGLEHWNSSFGIDP--EKKILKSADSNADS 73

  Fly   165 NVGFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDG 229
            .:.|.||:.|:::|||.:.|.|..||||.||.:|..|:::|.|.||:.|.:.:|.::|..||.||
  Rat    74 GLDFGEFVKYLQDHEKKMKLAFKSLDKNADGVIDASEVVAAMKSLGIHISLAQANDILKSMDADG 138

  Fly   230 SLNISFNEWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGI 294
            |:.:.::||||:....|:.::.|:|:||:|||.:||||.:::||:||::|.::|.||:.|||.||
  Rat   139 SMTVDWDEWRDYFFFHPAKNVTDIIRFWKHSTIIDIGESVSIPDEFTEQEKKSGEWWKRLVAAGI 203

  Fly   295 AGAVSRTCTAPLDRIKVYLQVQTQRMGISECMHI---MLNEGGSRSMWRGNGINVLKIAPETAFK 356
            |.|::|||||||||:||.:|||:.:|.....:|:   |:.|||..|:|||||:|:.||.||||.|
  Rat   204 ASAITRTCTAPLDRLKVMIQVQSSKMSKLRLVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIK 268

  Fly   357 FAAYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAA 421
            ..||||.|:|:..:|.:  :..::||.||:.||..|||.:||:||:||||.|.|||:::||.|..
  Rat   269 IGAYEQYKKLLSFEDAN--LGFLQRFTAGSMAGITSQTCVYPLEVIKTRLILGRTGEFSGIIDCG 331

  Fly   422 VKIYKQEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANH-DNNEQPSFLVLLACGSTSS 485
            .|:.::||:::|.||||||:|.|:||||:||.::|.||..::.:: :::..|...::|.|.:.|.
  Rat   332 RKLLRREGIQAFSRGYVPNLLSIVPYAGLDLTIFELLKNYWLEHYAESSVNPGLAIVLGCSTLSH 396

  Fly   486 TLGQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLY 550
            |.|||.|:||.|||||:||...|       ...||            |..|.::|..:||..|.:
  Rat   397 TFGQLASFPLNLVRTRMQAAMLE-------NETIP------------MMQLIQEIYTKEGKKGFF 442

  Fly   551 RGITPNFLKVLPAVSISYVVYEYTSRALGI 580
            ||:|||.||:||||.|..|.:|..:...|:
  Rat   443 RGLTPNVLKLLPAVGIGCVAHELVNLLFGL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	54/146 (37%)
		EFh	116..176	CDD:238008	22/65 (34%)
		EFh	186..242	CDD:238008	25/55 (45%)
		Mito_carr	285..370	CDD:278578	49/87 (56%)
		Mito_carr	375..463	CDD:278578	45/87 (52%)
		Mito_carr	470..581	CDD:278578	42/111 (38%)
Slc25a54	NP_001103110.1	PTZ00184	17..147	CDD:185504	48/131 (37%)
		EFh	28..85	CDD:238008	20/58 (34%)
		EFh	90..149	CDD:238008	24/58 (41%)
		Mito_carr	194..279	CDD:278578	48/84 (57%)
		Mito_carr	286..376	CDD:278578	45/89 (51%)
		Mito_carr	389..471	CDD:278578	40/100 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8179
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1419
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.840