DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and Slc25a23

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001365996.1	Gene:	Slc25a23 / 66972	MGIID:	1914222	Length:	480	Species:	Mus musculus

Alignment Length:	497	Identity:	246/497 - (49%)
Similarity:	328/497 - (65%)	Gaps:	56/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EDEERLERIFNKLDRDGDGRIDIHDLSAALHEF----------GLSSVYAEKFLQQSDKDQSGNV 166
            |..:|..|:|.:||.:.|||:|:|:|...|...          |:||.:        |.|..|.:
Mouse     9 ERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGRGDPDRAQQGVSSDW--------DADPDGGL 65

  Fly   167 GFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGSL 231
            ...||..|::|.|:.|:|.|..||:|:||.:|:.|:..:|:.||:.|.:::|..:|..||:||::
Mouse    66 SLEEFTRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTM 130

  Fly   232 NISFNEWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAG 296
            .|.:.||||..||....::.|::.||:|||.|||||.:.|||:|:|:|..||:||:.||||.:||
Mouse   131 TIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSQEEKLTGMWWKQLVAGAVAG 195

  Fly   297 AVSRTCTAPLDRIKVYLQV---QTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFA 358
            |||||.||||||:||::||   ::.|:.|...:..|:.|||..|:||||||||||||||:|.||.
Mouse   196 AVSRTGTAPLDRLKVFMQVHASKSNRLNILGGLRNMIQEGGVLSLWRGNGINVLKIAPESAIKFM 260

  Fly   359 AYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPME-------------VLKTRLALRR 410
            ||||:||.|||.  ...:.:.|||.||:.||..:||||||||             ||||||.|||
Mouse   261 AYEQIKRAIRGQ--QETLHVQERFVAGSLAGATAQTIIYPMEVRRRGWRKIQHGRVLKTRLTLRR 323

  Fly   411 TGQYAGIADAAVKIYKQEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANHDN-NEQPSF 474
            ||||.|:.|.|.:|.::||.|:|||||:||:|||:||||||||||||||.|::..:.: :..|..
Mouse   324 TGQYKGLLDCAKRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNRWLQQYSHESANPGI 388

  Fly   475 LVLLACGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEE-TMTGLFR 538
            ||||.||:.|||.||:.||||||||||:||||:                  ...|.: :|.||.|
Mouse   389 LVLLGCGTISSTCGQIASYPLALVRTRMQAQAS------------------IEGGPQVSMVGLLR 435

  Fly   539 KIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRALGI 580
            .|:.|||:.||||||.|||:||:|||||||||||...:|||:
Mouse   436 HILSQEGVWGLYRGIAPNFMKVIPAVSISYVVYENMKQALGV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	51/144 (35%)
		EFh	116..176	CDD:238008	21/69 (30%)
		EFh	186..242	CDD:238008	23/55 (42%)
		Mito_carr	285..370	CDD:278578	55/87 (63%)
		Mito_carr	375..463	CDD:278578	60/100 (60%)
		Mito_carr	470..581	CDD:278578	60/112 (54%)
Slc25a23	NP_001365996.1	FRQ1	7..142	CDD:227455	49/140 (35%)
Slc25a23	NP_001365996.1	PTZ00169	189..475	CDD:240302	170/305 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5237
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1462
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm42487
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770