DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCaMC and slc25a25

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_017951721.1	Gene:	slc25a25 / 496462	XenbaseID:	XB-GENE-5933194	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	263/535 - (49%)
Similarity:	348/535 - (65%)	Gaps:	63/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GLQHAHLATSSTTNTPLAYDLHEVASS---GSIL---PTEIPIEDEERLERIFNKLDRDGDGRID 133
            |..|.|       :||.:..|....::   |.::   |     |.|.||:.:|.:||.:.||.|.
Frog    24 GAPHTH-------DTPASPSLAAALAADPCGGLVCGGP-----EHETRLQILFQELDVNKDGGIC 76

  Fly   134 IHDLSAALHEFGLSSVYAE--KFLQQSDKDQSGNVGFAEFLHYVREHEKNLVLQFSHLDKNRDGK 196
            |:||:..|...|:.....|  |.::..||||.|.:.|.||:||:|:|||.|.|.|..|||..||:
Frog    77 INDLAVGLKRLGVHRTELELRKIVKAGDKDQDGQLDFEEFVHYLRDHEKKLRLVFKSLDKKNDGR 141

  Fly   197 VDLEELISAFKDLGLDIDMDEARNLL------------TRMDKDGSLNISFNEWRDFMLLAPSTD 249
            :|.:|::.:.:|||::|...:|..:|            |.|||:|::.|.:|||||:.||.|:.:
Frog   142 IDAQEIMQSLRDLGVNISEQQAEKILKRIRTGHRWGPVTHMDKNGTMTIDWNEWRDYHLLHPAEN 206

  Fly   250 IHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQ 314
            |.::|.:|:|||..|:||::.|||:||.:|.|||:|||||||||.||||||||||||||:||.:|
Frog   207 IPEIILYWKHSTIFDVGENLLVPDEFTVEEKQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQ 271

  Fly   315 VQTQRM-------GISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDG 372
            |...|.       |.::    |:.|||.||:||||||||:|||||:|.||.|||||||:|..|
Frog   272 VHASRSNNMSMLGGFTQ----MIREGGIRSLWRGNGINVIKIAPESAIKFMAYEQMKRIIGSD-- 330

  Fly   373 SRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYKQEGVRSFYRGY 437
            ...:.|.||..||:.||.|:|:.||||||||||:|||:||||.|:.|...||..:|||.:||:||
Frog   331 QETLGIHERLVAGSLAGVIAQSSIYPMEVLKTRMALRKTGQYQGMLDCGKKILLKEGVSAFYKGY 395

  Fly   438 VPNILGILPYAGIDLAVYETLKRRYIANH-DNNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTR 501
            |||:|||:||||||||||||||..::..: .::..|...||||||:.|||.|||.||||||||||
Frog   396 VPNMLGIIPYAGIDLAVYETLKNAWLQRYATSSADPGVFVLLACGTISSTCGQLASYPLALVRTR 460

  Fly   502 LQAQAAETIANQKRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSI 566
            :||:|:...|.|.                 ||:.||:.||:.||..|||||:.|||:||:|||||
Frog   461 MQAEASVEGAPQM-----------------TMSKLFKHIVKTEGAFGLYRGLAPNFMKVIPAVSI 508

  Fly   567 SYVVYEYTSRALGIK 581
            ||||||.....||::
Frog   509 SYVVYENLKLTLGVQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	62/166 (37%)
		EFh	116..176	CDD:238008	25/61 (41%)
		EFh	186..242	CDD:238008	25/67 (37%)
		Mito_carr	285..370	CDD:278578	59/91 (65%)
		Mito_carr	375..463	CDD:278578	57/87 (66%)
		Mito_carr	470..581	CDD:278578	59/110 (54%)
slc25a25	XP_017951721.1	EFh_PI-PLC	59..191	CDD:320029	50/131 (38%)
		EF-hand motif	59..88	CDD:320029	12/28 (43%)
		EF-hand motif	95..122	CDD:320029	12/26 (46%)
		EF-hand motif	127..154	CDD:320029	10/26 (38%)
		Mito_carr	242..328	CDD:365909	58/89 (65%)
		PTZ00169	247..501	CDD:240302	156/276 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62165
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1368
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm47587
Panther	1	1.100	-	-	LDO	PTHR24089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110