DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and slc25a24

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001004606.1	Gene:	slc25a24 / 447867	ZFINID:	ZDB-GENE-040912-183	Length:	477	Species:	Danio rerio

Alignment Length:	479	Identity:	238/479 - (49%)
Similarity:	331/479 - (69%)	Gaps:	28/479 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IEDEERLE---RIFNKLDRDGDGRIDIHDLSAALHEFGLS--SVYAEKFLQQSDKDQSGNVGFAE 170
            :|:|:..:   .:|.|||.:.||::|:.:|...|...|.|  ...|:|.:...|.|:...:.|.|
Zfish    16 LEEEDNTKSFAELFEKLDVNKDGKVDVSELKTGLAAMGFSMGKGEAQKIVTSGDTDKDEGLDFEE 80

  Fly   171 FLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGSLNISF 235
            |..|::||||.|.|.|..||||.||:||.:|:..:.||||:::...:|..:|..:|.||::.:.:
Zfish    81 FSKYLKEHEKKLRLTFKSLDKNEDGRVDAKEIQQSLKDLGINLSDKDAEKILHSIDVDGTMTLDW 145

  Fly   236 NEWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSR 300
            ||||:..|..|:.|:..:|::|:.||.||||:.:.:||:||::|..||:||:.|.|||:||||||
Zfish   146 NEWREHFLFNPAEDLQQIIRYWKKSTVLDIGDSLTIPDEFTEEEKTTGMWWKQLAAGGVAGAVSR 210

  Fly   301 TCTAPLDRIKVYLQV---QTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQ 362
            |.||||||:||::||   :|.::.:......|:.|||..|:|||||:||:|||||||.||.||||
Zfish   211 TGTAPLDRMKVFMQVHSSKTNKISLVNGFKQMIKEGGVASLWRGNGVNVIKIAPETAIKFMAYEQ 275

  Fly   363 MKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYKQ 427
            .|:|:..|.|..|..  |||.||:.||..:||.||||||:||||.||:||||:|:.|.|.||.::
Zfish   276 YKKLLSKDGGKVQSH--ERFMAGSLAGATAQTAIYPMEVMKTRLTLRKTGQYSGMFDCAKKILRK 338

  Fly   428 EGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANH-DNNEQPSFLVLLACGSTSSTLGQLC 491
            |||::||:|||||||||:||||||||||||||..::::: .:...|..||||.||:.|||.|||.
Zfish   339 EGVKAFYKGYVPNILGIIPYAGIDLAVYETLKNTWLSHYAKDTANPGVLVLLGCGTISSTCGQLA 403

  Fly   492 SYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITPN 556
            ||||||:|||:||.|:             ::.|:    :.:|:.|.:||:::||..||||||.||
Zfish   404 SYPLALIRTRMQAMAS-------------MEGSE----QVSMSKLVKKIMQKEGFFGLYRGILPN 451

  Fly   557 FLKVLPAVSISYVVYEYTSRALGI 580
            |:||:||||||||||||....|||
Zfish   452 FMKVIPAVSISYVVYEYMRSGLGI 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	51/140 (36%)
		EFh	116..176	CDD:238008	19/64 (30%)
		EFh	186..242	CDD:238008	23/55 (42%)
		Mito_carr	285..370	CDD:278578	51/87 (59%)
		Mito_carr	375..463	CDD:278578	59/87 (68%)
		Mito_carr	470..581	CDD:278578	58/111 (52%)
slc25a24	NP_001004606.1	PTZ00184	19..148	CDD:185504	46/128 (36%)
		EFh	25..86	CDD:238008	19/60 (32%)
		EFh	91..152	CDD:238008	25/60 (42%)
		Solcar 1	193..279		51/85 (60%)
		Mito_carr	195..284	CDD:278578	51/88 (58%)
		Solcar 2	287..372		59/86 (69%)
		Mito_carr	291..377	CDD:278578	58/85 (68%)
		Mito_carr	384..477	CDD:278578	58/109 (53%)
		Solcar 3	384..472		55/104 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5197
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1405
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm25152
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770