DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and aralar1

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	116/502 - (23%)
Similarity:	201/502 - (40%)	Gaps:	117/502 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 FNKLDRDGDGRIDIHDLS-----AALHE---FGLSSVYAEKFLQQSDKDQSGNVGFAEFLHYVRE 177
            |...||.|:|.:...|.:     ..||.   |.|...:.:::.  .||.|. .:.:|||...:.:
  Fly   114 FQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKRYF--GDKKQR-LINYAEFTQLLHD 175

  Fly   178 -HEKNLVLQFSHLDKNRDG---KVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGSLNISFNEW 238
             ||::.:..|...|....|   .:|.:::|...|           |:|||...:|..::::....
  Fly   176 FHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVK-----------RHLLTPGVRDNLVSVTEGHK 229

  Fly   239 RDFMLLAPSTDI---HDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSR 300
            ..|......|.:   .:|||    ..||                        |...|      ||
  Fly   230 VSFPYFIAFTSLLNNMELIK----QVYL------------------------HATEG------SR 260

  Fly   301 TCTAPLDRIKVYLQVQTQRMGISECMHIMLNEGGS--RSMW-----------RGNGINVLKIAPE 352
            |.....|:|.:..|..:|...:.  :.|:.:..|:  ::.|           |.:..::..||||
  Fly   261 TDMITKDQILLAAQTMSQITPLE--IDILFHLAGAVHQAGWWKRRRKIPPSSRIDYSDLSNIAPE 323

  Fly   353 TAFKFAAYE--QMKRLIRGDDGSRQMSIVE---RFYAGAAAGGISQTIIYPMEVLKTRLALRRTG 412
            ...|...:.  ::|.:....|.|..:.::|   ||..|:.||.:..|::||::::|||:..:|.|
  Fly   324 HYTKHMTHRLAEIKAVESPADRSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRAG 388

  Fly   413 QYAG-IA-----DAAVKIYKQEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANHDNNEQ 471
            .|.| :|     |...|:.:.||....|||.:|.::|:.|...|.|.|.:.::.:......|  .
  Fly   389 SYIGEVAYRNSWDCFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGN--I 451

  Fly   472 PSFLVLLA--CGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEETMT 534
            |::..:||  |...|..   :.:.||.:|:.|||. |.|..:..|.:..
  Fly   452 PTWAEVLAGGCAGASQV---VFTNPLEIVKIRLQV-AGEIASGSKIRAW---------------- 496

  Fly   535 GLFRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRALGIK 581
                .:||:.||.|||:|.....|:.:|..:|.:..|.:|...:..|
  Fly   497 ----SVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	30/137 (22%)
		EFh	116..176	CDD:238008	16/62 (26%)
		EFh	186..242	CDD:238008	11/58 (19%)
		Mito_carr	285..370	CDD:278578	19/99 (19%)
		Mito_carr	375..463	CDD:278578	30/96 (31%)
		Mito_carr	470..581	CDD:278578	27/112 (24%)
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234	6/19 (32%)
		EFh	84..135	CDD:298682	6/20 (30%)
		EF-hand_7	111..173	CDD:290234	16/61 (26%)
		Mito_carr	350..448	CDD:278578	30/97 (31%)
		PTZ00169	358..631	CDD:240302	57/208 (27%)
		Mito_carr	449..539	CDD:278578	28/115 (24%)
		Mito_carr	544..633	CDD:278578
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840