DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and slc25a25a

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_998422.1	Gene:	slc25a25a / 406541	ZFINID:	ZDB-GENE-040426-2396	Length:	469	Species:	Danio rerio

Alignment Length:	481	Identity:	241/481 - (50%)
Similarity:	333/481 - (69%)	Gaps:	29/481 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 IPIEDEERLERIFNKLDRDGDGRIDIHDLSAAL--HEFGLSSVYAEKFLQQSDKDQSGNVGFAEF 171
            :|:.:.:::|..:.:.:........:..||..|  .||.....:.:|.|:..:|:..|.:.|.||
Zfish     8 VPVHNSDQIEVEYFESNGLPSELKSLKSLSVLLPSQEFSTYRRWRKKSLKTEEKEHDGQLDFEEF 72

  Fly   172 LHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGSLNISFN 236
            :||:::|||:|.|.|..:|:...|:|:..:::::.:|||:.|.:.:|..:|..|||:|::.|.:|
Zfish    73 VHYLQDHEKDLKLVFKSMDRKIAGQVNANDIVNSLRDLGVHISLKQAEKVLKSMDKNGTMTIDWN 137

  Fly   237 EWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRT 301
            ||:.:..|.|:.:|.::|.:|:|||..|:||.:.|||:||.:|..||:||||||:||.|||||||
Zfish   138 EWKKYPTLQPAENIPEIILYWKHSTIFDVGESLMVPDEFTVEEHLTGMWWRHLVSGGGAGAVSRT 202

  Fly   302 CTAPLDRIKVYLQV---QTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQM 363
            |||||||:||.:||   |.:.|.:...:..|:.|||.||:||||||||:|||||||.||.||||:
Zfish   203 CTAPLDRLKVLMQVHGCQGKSMCLMSGLTQMIKEGGVRSLWRGNGINVIKIAPETALKFMAYEQI 267

  Fly   364 KRLIRGDDGSRQ--MSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYK 426
            ||::    ||.|  :.|.|||.||:.||.|:|:.||||||||||||||:||||.||:|.|..|.|
Zfish   268 KRVM----GSSQETLGISERFVAGSLAGVIAQSTIYPMEVLKTRLALRKTGQYKGISDCAKHILK 328

  Fly   427 QEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANH-DNNEQPSFLVLLACGSTSSTLGQL 490
            .||:.:||:|||||:|||:||||||||||||||..::..: ..|..|...||||||:.|||.|||
Zfish   329 TEGMSAFYKGYVPNMLGIIPYAGIDLAVYETLKNTWLQRYGTENADPGVFVLLACGTVSSTCGQL 393

  Fly   491 CSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITP 555
            .||||||:|||:||||                 |...|.:.:|||||::|::.||.||||||:||
Zfish   394 ASYPLALIRTRMQAQA-----------------SVEGSSQVSMTGLFKQIMKTEGPTGLYRGLTP 441

  Fly   556 NFLKVLPAVSISYVVYEYTSRALGIK 581
            |||||:|||||||||||:....||::
Zfish   442 NFLKVIPAVSISYVVYEHIKSTLGVR 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	40/139 (29%)
		EFh	116..176	CDD:238008	15/61 (25%)
		EFh	186..242	CDD:238008	18/55 (33%)
		Mito_carr	285..370	CDD:278578	57/87 (66%)
		Mito_carr	375..463	CDD:278578	61/89 (69%)
		Mito_carr	470..581	CDD:278578	62/110 (56%)
slc25a25a	NP_998422.1	EFh	82..141	CDD:298682	20/58 (34%)
		EF-hand_7	83..138	CDD:290234	17/54 (31%)
		Solcar 1	184..270		57/85 (67%)
		Mito_carr	186..272	CDD:278578	57/89 (64%)
		Mito_carr	276..369	CDD:278578	60/92 (65%)
		Solcar 2	278..363		60/84 (71%)
		Mito_carr	374..465	CDD:278578	60/107 (56%)
		Solcar 3	375..463		60/104 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5197
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1405
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm25152
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	1	1.100	-	-	O	PTHR24089
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840