DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCaMC and Slc25a16

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_038954788.1	Gene:	Slc25a16 / 361836	RGDID:	1311311	Length:	991	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	114/594 - (19%)
Similarity:	189/594 - (31%)	Gaps:	217/594 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EDQKQQHIDIDLTPDPASNFNFAQQAQANYSARTLAASYEHGQNLGLQHAHLATSSTTNTPLAYD 94
            :|.|:.|..|.||  |||...                  |.|..:|   :.:.|.........:.
  Rat   455 KDTKKSHQSIWLT--PASKLE------------------ESGNCIG---SLVRTEPVKRVCDGHY 496

  Fly    95 LHEVASSGSILPT-------EIPIEDEERLERIFNKLDRDGDGRIDIHDLSAALHEFGLSSVYAE 152
            ||........:|.       .|.:..|||  ::| .|.:....|||...::..| :..||::...
  Rat   497 LHNFQRKNGPMPATNLMAGDRIILSGEER--KLF-ALSKGYVKRIDTAAVTCLL-DRNLSTLPET 557

  Fly   153 KFLQQSDKDQSGNVGFAEFLHYVREHEKNLVL-QFSHLDKNRDGKVDLEELISAFKD-------- 208
            ...:...:::.|::              |..| ..|.|.:|.|....|.|||..||:
  Rat   558 TLFRLDREEKHGDI--------------NTPLGNLSKLMENTDSSKRLRELIIDFKEPQFIAYLS 608

  Fly   209 --LGLDIDMDEARNLLTRMDK---DGSLNISFNEWRDFMLL------APSTDIHDLIKF------ 256
              |..|. .|...|:|..::|   .....:..:  :|:.|:      ..:|.|..|::.
  Rat   609 SVLPHDA-KDTVANILKGLNKPQRQAMKKVLLS--KDYTLIVGMPGTGKTTTICALVRILSACGF 670

  Fly   257 ------WRHST--------------YLDIGEDMNVPDD---FTQKEM-----------QTGLWWR 287
                  :.||.              :|.:|:...|..|   ||::||           ...|:..
  Rat   671 SVLLTSYTHSAVDNILLKLAKFKIGFLRLGQSHKVHPDIQKFTEEEMCRLRSIASLAHLEELYNS 735

  Fly   288 HLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPE 352
            |.|       |:.||                 ||||   |.|.:                    .
  Rat   736 HPV-------VATTC-----------------MGIS---HPMFS--------------------R 753

  Fly   353 TAFKFAAYEQMKRL----------------IRGDDGSRQMSIVERFYAGAAAGGISQTIIYPME- 400
            ..|.|...::..::                :.||.......::.|   .|.|.|:|:::...:|
  Rat   754 KTFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHKQLPPLVLNR---EARALGMSESLFKRLER 815

  Fly   401 ----VLKTRLALRRTGQ---------YAG--------IADAAVKIYKQEGVR-SFYRGYVPNILG 443
                |::..:..|...:         |.|        :|:|.:.:...:.|| .||..|..|
  Rat   816 NESAVVQLTIQYRMNRKIMSLSNKLTYEGKLECGSDRVANAVITLPNLKDVRLEFYADYSDN--- 877

  Fly   444 ILPY-AGIDLAVYETLKRRYIANHDNNEQPSFLVLLACGSTSS-TLGQLCSYPLALVRTRLQAQA 506
              |: ||    |:|........|.|....|.   .:..|..|: |..:|..:   |..|.::|.|
  Rat   878 --PWLAG----VFEPDNPVCFLNTDKVPAPE---QIENGGVSNVTEARLIVF---LTSTFIKAAA 930

  Fly   507 AETIANQKR 515
            ...:|:..|
  Rat   931 PRILASSPR 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	34/173 (20%)
		EFh	116..176	CDD:238008	10/59 (17%)
		EFh	186..242	CDD:238008	17/68 (25%)
		Mito_carr	285..370	CDD:278578	13/100 (13%)
		Mito_carr	375..463	CDD:278578	23/111 (21%)
		Mito_carr	470..581	CDD:278578	11/47 (23%)
Slc25a16	XP_038954788.1	DNA2_N-like	127..366	CDD:411722
		TIGR00376	471..931	CDD:273041	102/566 (18%)
		DEXXQc_DNA2	625..828	CDD:350799	39/254 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910