DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCaMC and Slc25a23

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_017451808.1	Gene:	Slc25a23 / 301113	RGDID:	1588586	Length:	544	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	247/487 - (50%)
Similarity:	328/487 - (67%)	Gaps:	43/487 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EDEERLERIFNKLDRDGDGRIDIHDLSAALHEF----------GLSSVYAEKFLQQSDKDQSGNV 166
            |..:|..|:|.:||.:.|||:|:|:|...|...          |:||.:        |.|..|.:
  Rat     9 ERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGRGDPDRAQQGISSDW--------DSDADGGL 65

  Fly   167 GFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGLDIDMDEARNLLTRMDKDGSL 231
            ...||..|::|.|:.|:|.|..||:|:||.:|:.|:..:|:.||..|.|::|..:|..||:||::
  Rat    66 SLEEFTQYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGFSISMEQAEKILHSMDRDGTM 130

  Fly   232 NISFNEWRDFMLLAPSTDIHDLIKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAG 296
            .|.:.||||..||....::.|::.||:|||.|||||.:.|||:|:::|..||:||:.||||.:||
  Rat   131 TIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAG 195

  Fly   297 AVSRTCTAPLDRIKVYLQV---QTQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFA 358
            |||||.||||||:||::||   ::.|:.|...:..|:.|||..|:||||||||||||||:|.||.
  Rat   196 AVSRTGTAPLDRLKVFMQVHASKSNRLNILGGLRNMVQEGGLLSLWRGNGINVLKIAPESAIKFM 260

  Fly   359 AYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVK 423
            ||||:||.|.|.  ...:.:.|||.||:.||..:||||||||||||||.|||||||.|:.|.|.:
  Rat   261 AYEQIKRAICGQ--QETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARR 323

  Fly   424 IYKQEGVRSFYRGYVPNILGILPYAGIDLAVYETLKRRYIANHDN-NEQPSFLVLLACGSTSSTL 487
            |.::||.|:|||||:||:|||:||||||||||||||.|::..:.: :..|..|||||||:.|||.
  Rat   324 ILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNRWLQQYSHESANPGILVLLACGTISSTC 388

  Fly   488 GQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEE-TMTGLFRKIVRQEGLTGLYR 551
            ||:.||||||||||:||||:                  ...|.: :|.||.|.|:.|||:.||||
  Rat   389 GQIASYPLALVRTRMQAQAS------------------IEGGPQVSMVGLLRHILSQEGVWGLYR 435

  Fly   552 GITPNFLKVLPAVSISYVVYEYTSRALGIKMS 583
            ||.|||:||:|||||||||||...:|||:..|
  Rat   436 GIAPNFMKVIPAVSISYVVYENMKQALGVTSS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	52/144 (36%)
		EFh	116..176	CDD:238008	21/69 (30%)
		EFh	186..242	CDD:238008	24/55 (44%)
		Mito_carr	285..370	CDD:278578	54/87 (62%)
		Mito_carr	375..463	CDD:278578	60/87 (69%)
		Mito_carr	470..581	CDD:278578	61/111 (55%)
Slc25a23	XP_017451808.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5177
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1419
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm44551
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.780