DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCaMC and Slc25a25

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_666230.2	Gene:	Slc25a25 / 227731	MGIID:	1915913	Length:	514	Species:	Mus musculus

Alignment Length:	519	Identity:	260/519 - (50%)
Similarity:	341/519 - (65%)	Gaps:	53/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DLHEVASSGSILPTEI--PI--------EDEERLERIFNKLDRDGDGRIDIHDLSAALHEFGLSS 148
            |....|||.:..|..:  |.        :.:.||..:|..||.:.||.:.::||:..|...||..
Mouse    16 DAAATASSSASSPASVGDPCGGAVCGGPDHQLRLWSLFQTLDVNRDGGLCVNDLAVGLRRLGLHR 80

  Fly   149 VYAE--KFLQQSDKDQSGNVGFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELISAFKDLGL 211
            ...|  |.:|..|||..|.:.|.||:||:::|||.|.|.|..|||..||::|.:|::.:.:|||:
Mouse    81 TEGELRKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGV 145

  Fly   212 DIDMDEARNLLTR------------MDKDGSLNISFNEWRDFMLLAPSTDIHDLIKFWRHSTYLD 264
            .|...:|..:|.|            |||:|::.|.:|||||:.||.|..:|.::|.:|:|||..|
Mouse   146 KISEQQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFD 210

  Fly   265 IGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQRMGISECMHI- 328
            :||::.|||:||.:|.|||:|||||||||.||||||||||||||:||.:||...|   |..|.|
Mouse   211 VGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR---SNNMCIV 272

  Fly   329 -----MLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDGSRQMSIVERFYAGAAA 388
                 |:.|||::|:||||||||||||||:|.||.||||||||:..|  ...:.|.||..||:.|
Mouse   273 GGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSD--QETLRIHERLVAGSLA 335

  Fly   389 GGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYKQEGVRSFYRGYVPNILGILPYAGIDLA 453
            |.|:|:.||||||||||:|||:||||:|:.|.|.:|..:|||.:||:||:||:|||:||||||||
Mouse   336 GAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLA 400

  Fly   454 VYETLKRRYIANHD-NNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQKRKT 517
            ||||||..::..:. |:..|...||||||:.|||.|||.||||||||||:||||
Mouse   401 VYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQA----------- 454

  Fly   518 QIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRALGIK 581
                  |...:.|.||:.||::|:|.||..|||||:.|||:||:|||||||||||.....||::
Mouse   455 ------SIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	60/170 (35%)
		EFh	116..176	CDD:238008	24/61 (39%)
		EFh	186..242	CDD:238008	25/67 (37%)
		Mito_carr	285..370	CDD:278578	61/90 (68%)
		Mito_carr	375..463	CDD:278578	56/87 (64%)
		Mito_carr	470..581	CDD:278578	60/110 (55%)
Slc25a25	NP_666230.2	EF-hand_7	52..109	CDD:290234	21/56 (38%)
		EFh	53..110	CDD:238008	22/56 (39%)
		EFh	115..186	CDD:238008	25/70 (36%)
		EF-hand_7	116..183	CDD:290234	22/66 (33%)
		Mito_carr	231..319	CDD:278578	61/90 (68%)
		Mito_carr	321..413	CDD:278578	56/91 (62%)
		Mito_carr	419..510	CDD:278578	58/107 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5237
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62165
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1462
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55854
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm42487
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	1	1.100	-	-	LDO	PTHR24089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860