DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCaMC and SLC25A25

DIOPT Version :9

Sequence 1:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001317917.1	Gene:	SLC25A25 / 114789	HGNCID:	20663	Length:	515	Species:	Homo sapiens

Alignment Length:	523	Identity:	265/523 - (50%)
Similarity:	345/523 - (65%)	Gaps:	47/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 AHLATSSTTNTPLAYDLHEVASSGSILPTEIPIEDEERLE--RIFNKLDRDGDGRIDIHDLSAAL 141
            |..|.||:.::|        ||.|......|....:.||.  |:|..||.:.||.:.::||:..|
Human    18 AATAASSSASSP--------ASVGDPCGGAICGGPDHRLRLWRLFQTLDVNRDGGLCVNDLAVGL 74

  Fly   142 HEFGLSSVYAE--KFLQQSDKDQSGNVGFAEFLHYVREHEKNLVLQFSHLDKNRDGKVDLEELIS 204
            ...||.....|  |.:|..|||..|.:.|.||:||:::|||.|.|.|..|||..||::|.:|::.
Human    75 RRLGLHRTEGELQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQ 139

  Fly   205 AFKDLGLDIDMDEARNLLTR------------MDKDGSLNISFNEWRDFMLLAPSTDIHDLIKFW 257
            :.:|||:.|...:|..:|.|            |||:|::.|.:|||||:.||.|..:|.::|.:|
Human   140 SLRDLGVKISEQQAEKILKRIRTGHFWGPVTYMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYW 204

  Fly   258 RHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQR--- 319
            :|||..|:||::.|||:||.:|.|||:|||||||||.||||||||||||||:||.:||...|
Human   205 KHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNN 269

  Fly   320 MGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDGSRQMSIVERFYA 384
            |||......|:.|||:||:||||||||||||||:|.||.||||:|||:..|  ...:.|.||..|
Human   270 MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSD--QETLRIHERLVA 332

  Fly   385 GAAAGGISQTIIYPMEVLKTRLALRRTGQYAGIADAAVKIYKQEGVRSFYRGYVPNILGILPYAG 449
            |:.||.|:|:.||||||||||:|||:||||:|:.|.|.:|..:|||.:||:|||||:|||:||||
Human   333 GSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 397

  Fly   450 IDLAVYETLKRRYIANHD-NNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQ 513
            ||||||||||..::.::. |:..|...||||||:.|||.|||.||||||||||:||||
Human   398 IDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQA------- 455

  Fly   514 KRKTQIPLKSSDAHSGEETMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRAL 578
                      |...:.|.||:.||:.|:|.||..|||||:.|||:||:|||||||||||.....|
Human   456 ----------SIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITL 510

  Fly   579 GIK 581
            |::
Human   511 GVQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	60/162 (37%)
		EFh	116..176	CDD:238008	25/63 (40%)
		EFh	186..242	CDD:238008	25/67 (37%)
		Mito_carr	285..370	CDD:278578	61/87 (70%)
		Mito_carr	375..463	CDD:278578	57/87 (66%)
		Mito_carr	470..581	CDD:278578	60/110 (55%)
SLC25A25	NP_001317917.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5408
eggNOG	1	0.900	-	-		E1_KOG0036
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62165
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1481
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55854
OrthoDB	1	1.010	-	-		D333952at33208
OrthoFinder	1	1.000	-	-		FOG0000464
OrthoInspector	1	1.000	-	-		otm40414
orthoMCL	1	0.900	-	-		OOG6_100689
Panther	1	1.100	-	-	LDO	PTHR24089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1887
SonicParanoid	1	1.000	-	-		X287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870