DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-2 and Smyd3

DIOPT Version :9

Sequence 1:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	87/387 - (22%)
Similarity:	143/387 - (36%)	Gaps:	99/387 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 LRTGDVLLFEEPVAACLEPSYFGTHCHHCFKRLHTPVSCLHCSGIAFCSAQCMGEACSSYHRFEC 338
            ::.|..:|.|:|.|..|:..|....|.:|.:.... :.|.:|..:::|...|..:|... |:.||
  Fly    35 IKRGQRILTEKPFAFVLKSQYRLERCDNCLEATKV-LKCSNCRYVSYCHRSCQMQAWGQ-HKHEC 97

  Fly   339 EYM----DLMIGSGMSILCFIALRIFTQAPSLEQGLAT--ANLLFEHLCSHEEDRQPD------- 390
            .::    ..::.....:||.:.||: .....|.:|..|  .:..|..|.||..:.:.|
  Fly    98 PFLKKVHPRVVPDAARMLCRLILRL-EHGGDLIRGYYTEHGSRKFRDLMSHYAEIKNDPMRLEHL 161

  Fly   391 DYLRRAL---MSGFLLRILQK----SLYFGRRKTEGVNPTAVEL-QVATALLGLLQVLQYNAHQI 447
            |.|...|   |:.....:..|    |:| ||..|.|.|....|: .:|||
  Fly   162 DSLHAVLTDMMAESPSTVPNKTELMSIY-GRLITNGFNILDAEMNSIATA--------------- 210

  Fly   448 YQTQVTEEHRFDGSKTVYLAAGLYGTGSYFNHECWPSTACHFVGKKLVLTATRPHRANELVAVNY 512
                            :||..      |..:|.|.|:....|.|.:|     ..|...::..:::
  Fly   211 ----------------IYLGV------SITDHSCQPNAVATFEGNEL-----HVHAIEDMECLDW 248

  Fly   513 GPIFIK-----NNLKERQRSLRGRYSFSCSCMAC---QENWPLLQKLDKQVRFWCTSANCSNLLK 569
            ..|||.     |..::|:..|:..|.|.|.|..|   :|:..:|..|       |.:.||...:.
  Fly   249 SKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKCTDAKESKEMLAAL-------CPNRNCGAGIS 306

  Fly   570 FPKDLAKDVRCPRCRKNISLKESVAKMIKIEELYREA----ARAMEAQKTVEAIELFKESLD 627
            ..::     .||||...||        .|:...:.||    ...:|..|.|..:::.|..||
  Fly   307 VDRN-----NCPRCDAGIS--------PKLRNAFNEAMTLTRHNLENMKDVAYLDVCKVCLD 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150
		zf-MYND	299..338	CDD:280009	8/38 (21%)
		SET	<474..513	CDD:279228	8/38 (21%)
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	8/38 (21%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X437
	4	3.740