DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-2 and SmydA-1

DIOPT Version :9

Sequence 1:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_610944.1	Gene:	SmydA-1 / 36581	FlyBaseID:	FBgn0033917	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	83/411 - (20%)
Similarity:	148/411 - (36%)	Gaps:	84/411 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 RLVETKDKGRFVVANEGLRTGDVLLFEEPVAACLEPSYFGTH-CHHCFKRLHTP--VSCLHCSGI 318
            ::...:..||.:||...::..:::|.|.|:..  .|:..... |..|...:...  :.|..| |.
  Fly    44 KIAHNEQLGRHLVATRTIKPYEIVLKEAPLVR--GPAQISAPVCLGCLNGIEAEDHIECEQC-GW 105

  Fly   319 AFCSAQCMGEACSSYHRFECEYMDLMIGSGMSILCFIALRIFTQAPSLEQGLATANLL------- 376
            ..|..:|..   ...|:.||   .|....|..    :.::.|.....|...|:|...|
  Fly   106 PLCGPECKS---LDEHKAEC---GLTKDRGQK----VNVQEFGGPHPLYTCLSTVRCLLIGETST 160

  Fly   377 -----FEHLCSHEEDRQPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVNPTAVELQVATALLGL 436
                 |:.|.|.|..|:..:..:..|:|  :.:.:.|  :|..:|.     |..|:..|   :|.
  Fly   161 EKASKFQDLESLESTRRGSNQWKADLVS--IGQFIPK--FFKTQKF-----TEEEIMKA---VGA 213

  Fly   437 LQVLQYNAHQIYQTQVTEEHRFDGSKTVYLAAGLYGTGSYFNHECWPSTACHF-VGKKLVLTATR 500
            ||:   |.|::..|..:.             ..::.|.|:..:.|.|:.|..| .....:|.|.|
  Fly   214 LQI---NGHEVPTTDPSH-------------VAVFYTASFTENSCLPNLAKSFNKNGHCILWAPR 262

  Fly   501 PHRANELVAVNYGPIFIKNNLKERQRSLRGRYSFSCSCMACQENWPLLQKLDKQV-RFWCTSANC 564
            ..:.|..:::.|.....  ...:|||.|.....|.|:|..|.:    :.:||... ...|....|
  Fly   263 EIKKNAHLSICYSDAMW--GTADRQRHLMQTKLFKCACERCVD----VTELDTNYSAIKCEDRQC 321

  Fly   565 SNLLKFPK--DLAKDVRCPRCRKNISLKESVAKMIKIEELYREAARAMEAQKTVEAIELFKESLD 627
            ..|:...|  :.....||..|.|.:. |..|.::::            .|.|.::::|...|:
  Fly   322 GGLMLPTKADEWNGSWRCRECHKQVQ-KHYVERILE------------RAGKDIQSMEKIAEN-- 371

  Fly   628 MFFQVAALPHKDTIVAQQSLH 648
               .:..|.|.:..:..|..|
  Fly   372 ---GLKYLKHYEKWLPPQHFH 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150
		zf-MYND	299..338	CDD:280009	8/40 (20%)
		SET	<474..513	CDD:279228	9/39 (23%)
SmydA-1	NP_610944.1	zf-MYND	4..40	CDD:280009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810