Protein Alignment Smyd4-2 and Smyd4-1

DIOPT Version :10

• Sequence 1: NP_648574.1
• Gene: Smyd4-2 / 39414
• FlyBaseID: FBgn0036282
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 169/765 - (22%)
• Similarity: 283/765 - (36%)
• Gaps: 198/765 - (25%)

  Fly    42 NY------FGKLKSNAARVLSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMS 100
            ||      |..|.|..|.:|.||  :::...:|..||  |||.::..|..|...|.:.:.::..|
  Fly    20 NYKDEFETFKSLASMPADILQIF--QKLALDLLQDLE--QPVDRKGCAERSKNLREEGNLMFKES 80

  Fly   101 GSGDGEESRELLQQALMAANL---AVMRAPDRNADPVLDEGLTLALAYRSRASILIRLGEGEAAL 162
            .||..::|      .|.|..|   ||..|  .||   ::|   |:||:.:|...|...|....|.
  Fly    81 ASGSSKDS------VLKACRLYSEAVFEA--ENA---VEE---LSLAFANRGIALQEYGYYREAY 131

  Fly   163 NDLKLAINFGLELKSSVDYYLKMA------KAYAVMGEPARAEISLKIAEKMPGCDATHIALCRK 221
            :|...|:..|...:......::.|      |..|.:.|.......|::.|..    ...:...::
  Fly   132 DDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEEHLDYLGQLQLKESF----EQQLEDLKQ 192

  Fly   222 ELSSVKPKPKE-ATSEQVPQLAHGESAELVGASKVVRLVETKDKGRFVVANEGLRTGDVLLFEEP 285
            :|..:|.:|:| .|..:|...:.||.           |.:...:||::||.|.:..|:|:..|.
  Fly   193 KLELLKNQPREQETQGKVVDKSLGEI-----------LTDPGPRGRYMVAKEAISKGNVIFSER- 245

  Fly   286 VAACLEPSYFGTHCHHCFKRL-HTPVSCLHC-SGIAFCSAQCMGEACSSYHRFECE--YMDLMIG 346
             |:|..|......|..|...| ..|:.|.:| ..:.:||.:|. ||.|:.|:|||.  ..|::..
  Fly   246 -ASCFVPLEQLLICQQCAATLMSAPIPCPNCHQRVVYCSRKCR-EAHSAIHKFECAAYRKDILRL 308

  Fly   347 SGMSILCFIALR-IFTQAPSLE---QGLATANLLFEHLCS----HEEDRQPDDYLRRALMSGFLL 403
            .|:|   .:||| :.|..|.:.   |.:.:|..::|.:.:    .||.....:|||...|...|.
  Fly   309 LGIS---HLALRLLLTYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQLD 370

  Fly   404 RILQKSLYFG-----------RRKTEGVN-----PTAVE---LQVATALLGLLQVLQYNAH---- 445
            :.:.:.|.:.           :..|:..:     |.::|   |.::..:|.....|..|.|
  Fly   371 QAIDEELNYHILCANLLQLYLKEHTDFYDQFHSLPASIEDWQLIISALILRFAGQLLANGHVGDA 435

  Fly   446 -----------QIYQTQVTEE---------HRFDGSKTV------YLAAGLYGTGSYFNHECWPS 484
                       .:.|.::.::         |....|..:      ||        |..||.|.||
  Fly   436 LLGVGMEPKEFVMLQPELWQKPRHLKRGQLHNLSHSDPITAINLPYL--------SLCNHACEPS 492

  Fly   485 TACHFVGKKLVLTATRPHRANELVAVNYGPIFIKNNLK-ERQRSLRGRYSFSCSCMACQENWPLL 548
            ....|.|..:|..|.:.....|.: .|...:..:|:|| :|...|:..|.|.|:|..|....|..
  Fly   493 IRTKFDGCSVVNYAAKDILEGEEI-FNCYTMDYRNSLKLQRSHPLKAIYKFECTCAKCTRTDPDQ 556

  Fly   549 QKLDKQVRFWCTSANC------------SNLLKFPK-DLAKDVRCPRCRK--------------- 585
            ..|... |:.|...||            :||..:.: :..|.:.|..|.:
  Fly   557 NYLSFH-RYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAEKPITCTVCHELQHFAWYNEFLGLIG 620

  Fly   586 ---NISLKESV----------------AKMIKIEEL------------------YREAARAMEAQ 613
               :.|.::::                .|.|..|||                  |.:.||.:..|
  Fly   621 SSADSSKRQALFKAFDDLDKWLVDHHSLKRIMAEELVTACFYEIDGGTSLDEFEYEDLARIIRKQ 685

  Fly   614 KTVEAIELFKESLDMFFQVAALPHKDTIVAQQSLHKCLSDTGTTFKKEGK 663
            ....|.:....|.:   .:|.:.:...|:||:   ||.:|.....:.:||
  Fly   686 LEGIAAQCGDNSTE---YIARMTYLWDIIAQK---KCRTDRKELLEMKGK 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	BepA	87..205	CDD:443813	29/126 (23%)
		SET_SMYD4	249..541	CDD:380934	81/353 (23%)
		zf-MYND	299..338	CDD:460312	14/40 (35%)
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	12/47 (26%)
		zf-MYND	258..298	CDD:460312	14/40 (35%)
		SET	<359..549	CDD:394802	40/198 (20%)