DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-2 and Smyd5

DIOPT Version :9

Sequence 1:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_659167.2	Gene:	Smyd5 / 232187	MGIID:	108048	Length:	416	Species:	Mus musculus

Alignment Length:	388	Identity:	82/388 - (21%)
Similarity:	133/388 - (34%)	Gaps:	116/388 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 AELVGASKVVRLVET-KDKGRFVVANEGLRTGDVLLFEEPVAA----------------CL---- 290
            |:....|..||.|:: |.||.|  |.:.:|.|:.:..|.|:.|                ||
Mouse    16 ADRARGSVEVRYVDSIKGKGLF--ATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALE 78

  Fly   291 -----------EPSYFGTHCHHCFKRLHTPVSCLHCSGIAFCSAQCMGEACSSYHRFEC------ 338
                       :||....|...|..|.....:|.||. :.:|||:|...|...||:..|
Mouse    79 KAEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQ-VMYCSAECRLAAAEQYHQILCPGPSHD 142

  Fly   339 -------------------EYMDLMIGSGMSILCFIALRIFTQAPSLEQGLATANLLFEHLCSHE 384
                               |...:|:.:.|       :....||...:..:.    ||.|.||..
Mouse   143 PRHPLNKLQEAWRSVHYPPETASIMLMARM-------VATVKQAKDKDHWVR----LFNHFCSRT 196

  Fly   385 EDRQPDDYLRRALMSG-------FLLRILQKSLY----------------FGRRKTEGVNPTAVE 426
            .::  :..:...|:.|       .||.:.:::||                |....|.|.......
Mouse   197 ANQ--EQAIVHKLLKGKFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSS 259

  Fly   427 LQVATALLGLLQVLQYNAHQIYQTQVTEEHR-FDGSKTVYL---AAGLYGTGSYFNHECWPSTAC 487
            |.........|::...:..|: .|.:.:.:: .:.:...:|   .:||:...|..||.|.|:...
Mouse   260 LSQWVHACDALELTPQDREQL-DTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAET 323

  Fly   488 HFVGKKLVL--TATRPHRANELVAVNYGPIFIKNNLKERQRS-------LRGRYSFSCSCMAC 541
            .|.....||  ||....:..|.:.::|      .:..:|:||       ||..|.|:|||..|
Mouse   324 SFPENNFVLHVTALEDIKPGEEICISY------LDCCQRERSRHSRHKILRENYLFNCSCPKC 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150
		zf-MYND	299..338	CDD:280009	12/38 (32%)
		SET	<474..513	CDD:279228	11/40 (28%)
Smyd5	NP_659167.2	SET	<297..350	CDD:214614	14/52 (27%)
Smyd5	NP_659167.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810