DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-2 and set-10

DIOPT Version :9

Sequence 1:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_493620.2	Gene:	set-10 / 185237	WormBaseID:	WBGene00009370	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	76/345 - (22%)
Similarity:	146/345 - (42%)	Gaps:	70/345 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 EEPVAACLEPSYFGTHCHHCFKRLHTP-----VSCLHCSGIAFCSAQCMGEACSSYHRFECEYMD 342
            |:|:||.|.|.:...:|..||..:.:.     ::|..|..:::|:.:|..:...|.|:||||.:.
Worm     7 EQPLAAVLSPQFSELYCATCFLEIDSSQETEILTCDDCLAVSYCTLKCQRKDWKSCHQFECEILR 71

  Fly   343 LMIGSG--MSILCFIALRIF-----TQAPSLEQGLATANLLFEHL-CSHEEDRQPDDYLRRALMS 399
            .. ||.  |::...:.:|:.     ||.||..      ..:.|.| .:::|.|...::      :
Worm    72 CQ-GSSTPMTLTMKLCIRVLLASRSTQTPSFN------GAVLEDLETNYKEFRSSPEH------N 123

  Fly   400 GFL---LRILQKSLYFGRRKTEGVNPTAVELQVATALLGLLQVLQYNAHQIYQTQVTEEHRFDGS 461
            .||   |.|:..|       .:.:.||::|   ....:|::..:..|:..|...:..|.
Worm   124 QFLSDVLTIISSS-------GQNIFPTSLE---TNKTIGIICSVLCNSFSIINEKRVEP------ 172

  Fly   462 KTVYLAAGLYGTGSYFNHECWPSTACHFVGKKLVLTATRPHRANELVAVNYGPIFIKNNLKERQR 526
                :.:|||...:..||.|..::...|.|.::.|...:...:.|| .::|....:..:  ||::
Worm   173 ----IGSGLYVGVAKHNHSCASTSHVVFEGNQVFLRTNQEEYSKEL-TISYVSRMLPTS--ERRK 230

  Fly   527 SLRGRYSFSCSCMACQ-ENWPLLQKLDKQVRFWCTSANCSNLLKFPKDLAKDVRCPRCRK--NIS 588
            ::||.:..:|.|..|: |...|:....|     |.:.||:..:|      ....|..|.|  .:.
Worm   231 TIRGVHFLTCQCEMCKNEELDLIGLSSK-----CRTKNCTGFVK------GSGNCSVCEKLAFLP 284

  Fly   589 LKESVAKMIK----IEELYR 604
            .::|:...:.    ||.|::
Worm   285 FEQSIHSTLNLLDIIENLHK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150
		zf-MYND	299..338	CDD:280009	10/43 (23%)
		SET	<474..513	CDD:279228	8/38 (21%)
set-10	NP_493620.2	zf-MYND	23..67	CDD:366792	10/43 (23%)
set-10	NP_493620.2	SET	57..247	CDD:394802	49/225 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810