DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-2 and set-30

DIOPT Version :9

Sequence 1:	NP_648574.1	Gene:	Smyd4-2 / 39414	FlyBaseID:	FBgn0036282	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_508850.2	Gene:	set-30 / 180772	WormBaseID:	WBGene00022499	Length:	560	Species:	Caenorhabditis elegans

Alignment Length:	470	Identity:	93/470 - (19%)
Similarity:	149/470 - (31%)	Gaps:	142/470 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 ELVGASKVVRLVETKDKGRFVVANEGLRTGDVLLFEEPVAACLEPSYFGTHCHHCFKRLHTPVSC 312
            |:||..|:               ....|:.:...|...:..|.:..|    |..|... :..::|
Worm     9 EVVGVEKI---------------GSKPRSKEFYPFAYSLLDCTKDDY----CWTCLGE-NVELTC 53

  Fly   313 LHCSGIAFCSAQCMGEACSSYHRFEC---------------------EYMDLMIGSGMSILCFIA 356
            ..|....|||.||....... |::||                     .|.|:..|...||..|..
Worm    54 EQCKVAKFCSKQCETSGAID-HKYECGPLKKCPDLNTDERMLIRIVGRYKDIHSGKDKSIDGFYN 117

  Fly   357 LRIFTQAPSLEQGLATANLLFEHLCSHEEDRQPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVN 421
            .|         :...:...::||....::|..        .|..|      |..| .|.|..|..
Worm   118 NR---------ESKRSVMEIWEHCADMKKDEN--------AMKSF------KKTY-DRVKQFGDT 158

  Fly   422 PTAVELQVATALLGLLQVLQYNAHQIYQTQVTEEHRFDGSKTVYLAAGLYGTGSYFNHECWPST- 485
            ...::.:|...|.....:   |.|.|.......|          :..|||.....::|.|.|:.
Worm   159 NHLMDEEVTFQLHSRNFI---NRHSISNVDYLRE----------IGKGLYLDLCKYDHSCRPNAI 210

  Fly   486 -ACHFVGKKLVLTATRPHRA-------NELVAVNYGPIFIKNNLKERQRSLRGRYSFSCSCMAC- 541
             :|:.:..||        ||       ..:...:|..|.:.....:|:..|:..:.|.|.|..|
Worm   211 YSCNGIVAKL--------RALHDNVDLENVETTHYTYIELPPCKIQRRHMLKETWYFECHCERCD 267

  Fly   542 --QENW------PL-LQKLD--KQVRFWCTSANCSNLLKFPKDLAKDVRCPRCRKNISLKESVAK 595
              .:||      |: :.|.:  |.::.....|..:     |:.|  ::.|.||...:. :|.:..
Worm   268 DPDDNWLTSVLCPVCISKTEYRKTIKLHGPEAYAN-----PETL--EIVCDRCSTTLD-REYIFM 324

  Fly   596 MIKIEELYREAARAMEAQKTVEAIELFK----------ESLDM----FFQVAA----------LP 636
            .:......|......| .:|.:.|||.|          ..|.|    |.|:.|          :.
Worm   325 ALDGMRTIRRTVEGAE-DETKDPIELLKIYQGALMTYERILPMSNAYFCQLIAAMIPLISRVSMT 388

  Fly   637 HKDTIVAQQSLH-KC 650
            .|:.:||...|| ||
Worm   389 KKERLVASLDLHLKC 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-2	NP_648574.1	TPR_11	142..205	CDD:290150
		zf-MYND	299..338	CDD:280009	10/38 (26%)
		SET	<474..513	CDD:279228	8/47 (17%)
set-30	NP_508850.2	zf-MYND	41..78	CDD:366792	10/38 (26%)
set-30	NP_508850.2	SET_SMYD	<179..266	CDD:380997	21/104 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810