DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd4-2 and SMYD4

DIOPT Version :9

Sequence 1:NP_648574.1 Gene:Smyd4-2 / 39414 FlyBaseID:FBgn0036282 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_443160.2 Gene:SMYD4 / 114826 HGNCID:21067 Length:804 Species:Homo sapiens


Alignment Length:837 Identity:174/837 - (20%)
Similarity:285/837 - (34%) Gaps:260/837 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 DKWLRNYFGKLKSNAARVLSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMSG 101
            |:| ::|.  |:..|:...|:.......:.:..:..|...:.:.:|.||    ..:..|.||:..
Human     6 DEW-KSYL--LQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELF----LKRLSKGYLVGK 63

  Fly   102 SGDG-----EESRELLQQ-----ALMAANLAVMRAPDRNADPVLDEGLTLALAYRSRASILIRLG 156
            ..|.     ||..:..|:     |.:..:..|..:.....|        ::|.:.:|::.|..||
Human    64 DSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTED--------MSLCHANRSAALFHLG 120

  Fly   157 EGEAALNDLKLAINFGLELKSSVDYYLKMAKAYAVMGEPARAEISLK-----------IAEKMPG 210
            :.|..|.|:..|...|...:......|:.|:....:|....|..::.           :|:.:| 
Human   121 QYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLP- 184

  Fly   211 CDATHIALCRKELSSVKPK--PKEATSEQVP-QLA--------HGESAELVGASKVVRLVETKDK 264
                  ...::.|..:|.|  .|::.:|..| .||        ..|:.:|..||..:.|.....|
Human   185 ------QTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLK 243

  Fly   265 GRFVVANEGLRTGDVLLFEEPVAACLEP-----------SYFGT-------HCHHCFKRLHTPVS 311
            ||.:||.:.:..|::|:.|:...:.|.|           |.:.|       :||.|.|.....|.
Human   244 GRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVP 308

  Fly   312 CLHCSGIAFCSAQCMGEACSSYHRFECEYMDLMIGSGMSILCFIALRIF---------------- 360
            |..||...:||.:|:.:|...|||.||....|::..|  :.|.||||:.                
Human   309 CDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLG--VFCHIALRLTLLVGFEDVRKIITKLC 371

  Fly   361 --------------TQAPSLEQGLATA------------------------NLLFEHLCSHEEDR 387
                          .|..:|..||..:                        |.:| :|..|.|:.
Human   372 DKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVF-NLLPHTENH 435

  Fly   388 QPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVNPTAVELQV-----------ATALLGLLQVLQ 441
            .|:.....||....|.|.|:.:..........||.:.::..|           ..|:|..:..||
Human   436 SPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQ 500

  Fly   442 YNAHQIYQTQVTEEHR------FDGSKTVYLAAGLYGTGSYFNHECWPSTACHFVGKKLVLTATR 500
            .||    |...|.:|.      ...|:.|.||.|::...|..||.|.|:|:..|:.....:.|::
Human   501 CNA----QAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQ 561

  Fly   501 PHRANELVAVNYGPIFIKNNLKERQRSLRGRYSFSCSCMACQ---------ENWPLL-------- 548
            ..|..:.:...|||...:..:.|||:.||.:|.|.|:|.|||         ..|...        
Human   562 RIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAP 626

  Fly   549 QKLDKQVRFWCTSANCS-------NLLKFPKDLAKDVRCPRCRKNISLKESVAKMIKIEELYREA 606
            .:.|..:|  |.|.:|:       :|:...:||.:.||..:            |:::..||.|..
Human   627 MQGDDVLR--CGSRSCAESAVSRDHLVSRLQDLQQQVRVAQ------------KLLRDGELERAV 677

  Fly   607 ARAMEAQKTVEAI---------------------------------------------------- 619
            .|....|:..|:.                                                    
Human   678 QRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGH 742

  Fly   620 ELFKESLDMFFQVAALPH-------------------KDTIVAQQSLHKCLSDTGTT 657
            ||||.: .:||...|:|.                   .|.|...|.:..||.|...|
Human   743 ELFKLA-QIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPT 798

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Smyd4-2NP_648574.1 TPR_11 142..205 CDD:290150 14/73 (19%)
zf-MYND 299..338 CDD:280009 15/38 (39%)
SET <474..513 CDD:279228 9/38 (24%)
SMYD4NP_443160.2 TPR repeat 68..96 CDD:276809 4/27 (15%)
PLN03088 <72..>237 CDD:330826 34/179 (19%)
TPR repeat 101..135 CDD:276809 10/41 (24%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000250 112..114 1/1 (100%)
TPR repeat 143..171 CDD:276809 4/27 (15%)
zf-MYND 296..335 CDD:307734 15/38 (39%)
SET <528..574 CDD:307139 11/45 (24%)