DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32104 and RPAP1

DIOPT Version :9

Sequence 1:	NP_648573.2	Gene:	CG32104 / 39413	FlyBaseID:	FBgn0052104	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_056355.2	Gene:	RPAP1 / 26015	HGNCID:	24567	Length:	1393	Species:	Homo sapiens

Alignment Length:	1452	Identity:	365/1452 - (25%)
Similarity:	547/1452 - (37%)	Gaps:	387/1452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFKKLKPGESEEDVLRMAAEFNAERAKDPNFQPAAAFVR----------MDKAPKKSMFAQRREQ 55
            |..:.||||||.|:|...::|.|..|     .||...|:          .|:.|    ....|:.
Human     1 MLSRPKPGESEVDLLHFQSQFLAAGA-----APAVQLVKKGNRGGGDANSDRPP----LQDHRDV 56

  Fly    56 AKLGRV----TSTTEKNEEQIQPVPKEIIPQIPTSVPKER----GSHVSQVLLDEIQENILGDVK 112
            ..|..:    .:......::.:|.|...:|:  ...|:||    ..|::.| |.:|.|.....|.
Human    57 VMLDNLPDLPPALVPSPPKRARPSPGHCLPE--DEDPEERLRRHDQHITAV-LTKIIERDTSSVA 118

  Fly   113 GSKMDPSSLGNVLGELVERTEGTRRSAFP---------ETKNVDSSKPLSIFAKQLLGAKSSTKE 168
            .:...||.:                 |||         :.|:..|.| .||||:: :.|:...:.
Human   119 VNLPVPSGV-----------------AFPAVFLRSRDTQGKSATSGK-RSIFAQE-IAARRIAEA 164

  Fly   169 KSNKVSDF-----------------PRND-----------------TSSIIKDAKLGKE---LHQ 196
            |...|.:.                 |||.                 |...::|.:..:|   :|:
Human   165 KGPSVGEVVPNVGPPEGAVTCETPTPRNQGCQLPGSSHSFQGPNLVTGKGLRDQEAEQEAQTIHE 229

  Fly   197 ENLNVLKQMNEQDILTEKERLLASLDPSLIALLSKKRQTTPN-----SKPPNPNSPKVIEAPPMP 256
            ||:..|:.|..::||.|::||||.|||||:|.|.....|...     |:...|..|........|
Human   230 ENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQEQTGETASEEQRPGGPSANVTKEEP 294

  Fly   257 AQSTRAQDP-QISSLTDGNPAIELLQESDKGNWLNFNLVEEHKLAWMRDIPAKISELKPGEQFNA 320
            ..|..|.:| :...|....||:.|.....| .||:.:.||..||.|.:|:| .:...:..|:..|
Human   295 LMSAFASEPRKRDKLEPEAPALALPVTPQK-EWLHMDTVELEKLHWTQDLP-PVRRQQTQERMQA 357

  Fly   321 RFDWKGVLLPHTLKDQDASKQIDERELYLHGEEADRPGYALQELFRLARSTVLQQRLSAFGAIAG 385
            ||..:|.||   ..|.|....:.   |:.|||||:|.||:|||||.|.||.|.|||..|...:|.
Human   358 RFSLQGELL---APDVDLPTHLG---LHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQ 416

  Fly   386 IFSIYNQG-FYDQ----VLSLPISKIF-FLLRFGLDDNAPAQLEVVSRALSNLFYNETDEVLLDH 444
            :.|....| |.|:    ||||.:...| |||||.|||.....:....|||..|.....||.|||.
Human   417 VISRAQAGEFGDRLAGSVLSLLLDAGFLFLLRFSLDDRVDGVIATAIRALRALLVAPGDEELLDS 481

  Fly   445 VHDNAYCHWQPTLEVLGNGSDGNGEDTDTNSIAFLQRYMKLLTTSKSVRAEVDEDESESRTSMDD 509
            ..  ::.|...|..::.:..|...||.|....|              .:|:....|.|||...|
Human   482 TF--SWYHGALTFPLMPSQEDKEDEDEDEECPA--------------GKAKRKSPEEESRPPPD- 529

  Fly   510 FQLAETDLMDCLLRTNILQRIRFILVSVKPDNSTVESCLKLLIRIARTSTKVARQLANESHLIDT 574
              ||..|::..||.|::|.|:|::|....|..:.|...|.:|||:||.|.:.|.::.....||:|
Human   530 --LARHDVIKGLLATSLLPRLRYVLEVTYPGPAVVLDILAVLIRLARHSLESATRVLECPRLIET 592

  Fly   575 LFKHFLPSS------SGSNQFYGQPQVLFLKLIRVLICHHLDIAKGISKGV--------LITRLQ 625
            :.:.|||:|      ..:...|..|....:||:|||.....:||..:....        :|....
Human   593 IVREFLPTSWSPVGAGPTPSLYKVPCATAMKLLRVLASAGRNIAARLLSSFDLRSRLCRIIAEAP 657

  Fly   626 QYLFLQDNKVQMVRIQIEALRILRCLLLL---GIVDRDIFRQFLPALRQL---LDWHGNHCAFDG 684
            |.|.|...:.:|  :..||||:.......   |.:.|:::...:.||:.:   |..|
Human   658 QELALPPEEAEM--LSTEALRLWAVAASYGQGGYLYRELYPVLMRALQVVPRELSTH-------- 712

  Fly   685 VGGSGLVRQHAAALLVAL----VASGESGA--------------------CDVEGQKLLVEPL-- 723
             ....|..|..|:||..|    :|:|.:.|                    ..|.|.:.||||.
Human   713 -PPQPLSMQRIASLLTLLTQLTLAAGSTPAETISDSAEASLSATPSLVTWTQVSGLQPLVEPCLR 776

  Fly   724 -------------------------------------NNCCCGWMHAASRVAK---IKDFSQMTL 748
                                                 ::|...|:....|:::   :...||.||
Human   777 QTLKLLSRPEMWRAVGPVPVACLLFLGAYYQAWSQQPSSCPEDWLQDMQRLSEELLLPLLSQPTL 841

  Fly   749 LS---------------------------AALYAVGWFSRNSLLGTTSFLPFLRSILPKFVQSSG 786
            .|                           .:|...|...|.||.|:.|..|||.::|...    .
Human   842 GSLWDSLRHCSLLCNPLSCVPALEAPPSLVSLGCSGGCPRLSLAGSASPFPFLTALLSLL----N 902

  Fly   787 FIACVHDLVKGSIMLRRPIDRRHVHAPLPNVGAVL----MHDYGPQLVVSETYPVHLLS-NLWAL 846
            .:|.:|..:.|.:                  .|:|    :.:|..|.|.....| ||.. :.|||
Human   903 TLAQIHKGLCGQL------------------AAILAAPGLQNYFLQCVAPGAAP-HLTPFSAWAL 948

  Fly   847 --------LAISLDSGEKPLFEALIQPAVLEPLAEYLRQLSTQLNRVLATNFFARSELRFIHQLL 903
                    ||::|  .:|   .|.:||......|.|.......|:|:|
Human   949 RHEYHLQYLALAL--AQK---AAALQPLPATHAALYHGMALALLSRLL----------------- 991

  Fly   904 TTDGIEIYLKRQQMLQLVYNYLCCLSTAHATQIKSIFERFIFNG-----DFVKLDESSL------ 957
              .|.| ||..:.:|..|:            :::.:.||  .:|     ||  .|:.||
Human   992 --PGSE-YLTHELLLSCVF------------RLEFLPER--TSGGPEAADF--SDQLSLGSSRVP 1037

  Fly   958 -----KLLQQSCLEMVYPHI---------------IADNS--------EPSLSLSYTQAPILPTD 994
                 .||.|:|.::  |.|               :|..:        .|:|.|.....|:||||
Human  1038 RCGQGTLLAQACQDL--PSIRNCYLTHCSPARASLLASQALHRGELQRVPTLLLPMPTEPLLPTD 1100

  Fly   995 WPFFQLRVILSNYLQNVQQRPAAIHSENQV--VLMTLTFVRQLER---EGLQIVSPLEKLMYLMI 1054
            |||..    |..........|:.:...:.:  .:..|.:|..||.   :.|..|.|..:|..||.
Human  1101 WPFLP----LIRLYHRASDTPSGLSPTDTMGTAMRVLQWVLVLESWRPQALWAVPPAARLARLMC 1161

  Fly  1055 AFMGPDSQFLAPDLHELLRDCLMDFYRENAAHEFDFDAELVDKARFEPLYYLFVEHFEAASYGDE 1119
            .|:.....|....:..|:...|....:.......:.|..|.....|..||..|::||||.|:||.
Human  1162 VFLVDSELFRESPVQHLVAALLAQLCQPQVLPNLNLDCRLPGLTSFPDLYANFLDHFEAVSFGDH 1226

  Fly  1120 LFSSLVLVPLAQKYDNKWRRRLWSEHVQAVRFINCDESMLMGGLFAYLEPVEEEPSLVKLYGDAL 1184
            ||.:|||:||.:::....|..|:.|||.|:|.::...:.|...|..|..|.|:..:|::||...|
Human  1227 LFGALVLLPLQRRFSVTLRLALFGEHVGALRALSLPLTQLPVSLECYTVPPEDNLALLQLYFRTL 1291

  Fly  1185 AQKMVRPG--SIAYRIAQHHFN 1204
            ....:||.  .:.|.:|..|.|
Human  1292 VTGALRPRWCPVLYAVAVAHVN 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32104	NP_648573.2	RPAP1_N	193..234	CDD:285785	20/43 (47%)
CG32104	NP_648573.2	RPAP1_C	319..390	CDD:285784	32/70 (46%)
RPAP1	NP_056355.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..53		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..94		4/34 (12%)
		RPAP1_N	226..270	CDD:285785	20/43 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..295		4/28 (14%)
		RPAP1_C	356..421	CDD:285784	32/70 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531		11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154931
Domainoid	1	1.000	178	1.000	Domainoid score	I3593
eggNOG	1	0.900	-	-		E1_KOG1894
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2993
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52889
OrthoDB	1	1.010	-	-		D25908at2759
OrthoFinder	1	1.000	-	-		FOG0005659
OrthoInspector	1	1.000	-	-		oto90758
orthoMCL	1	0.900	-	-		OOG6_104902
Panther	1	1.100	-	-	LDO	PTHR21483
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1069
SonicParanoid	1	1.000	-	-		X6091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800