Protein Alignment Ncc69 and SLC12A6

DIOPT Version :9

• Sequence 1: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001352017.1
• Gene: SLC12A6 / 9990
• HGNCID: 10914
• Length: 1150
• Species: Homo sapiens
• Alignment Length: 1340
• Identity: 330/1340 - (24%)
• Similarity: 527/1340 - (39%)
• Gaps: 421/1340 - (31%)

  Fly    72 LEDDTFDATQMLNQRQPRQQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESND----- 131
            |.|.:.|.:...:.|.....|:|:..:.|.:..........:.....:||.::.:....|
Human    28 LSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDL 92

  Fly   132 SQ-----EERELLDN----------------EYDTKYGKSFRHFTRE---------ALPRLDNYR 166
            ||     |..:|||:                |.|..:.|:...|..|         .|.|:.||.
Human    93 SQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYT 157

  Fly   167 NMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLKFGWIKGVLVRCLLNIWGVML 231
            |:  .|.|...  :|..|.| .||...:.|    |:         .|...||.:.||.||:||:|
Human   158 NL--TQGAKEH--EEAENIT-EGKKKPTKT----PQ---------MGTFMGVYLPCLQNIFGVIL 204

  Fly   232 FLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFGGSIG 296
            ||||:||||.|||::.|.::|.....|.:||:|||||:||||:..||:|:||||:|||||||::|
Human   205 FLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVG 269

  Fly   297 LIFSLANAVACAMYVVGFCESML--------------------AMMTTFGWEIIDGGVQDVRIIG 341
            |.|.|....|.|||::|..|..|                    ||:            .::|:.|
Human   270 LCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAML------------NNMRVYG 322

  Fly   342 CITILLLLIIVVVGMEWE---AKAQIGLLIILLVAIGDFVIGSFIGP------------------ 385
            ...::|::::|.:|:.:.   |...:..:|:.::||....|.|...|
Human   323 TAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHI 387

  Fly   386 --------------------------------------KSDAEMAKGFLGYNATLFKNNLFADYR 412
                                                  .::....:|..|..:.:...||:::|.
Human   388 DVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYL 452

  Fly   413 P-----EK---------GGIQHDFFSV---------FAIFFPAATGILAGANISGDLKDPQKSIP 454
            |     ||         |.:.|::..|         ..||||:.|||:||:|.||||||.|||||
Human   453 PKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIP 517

  Fly   455 KGTILAIVITTGTYLIMVLQCGA----TVARDATGNLSDVVNGTFAFLDCQPGECNYGLQNSFQV 515
            .||||||:.|:..||..|:..||    .|.||..|   |.|.|..                   |
Human   518 IGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFG---DAVKGNL-------------------V 560

  Fly   516 IELVSAFGP-LIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NNEPVRGY 578
            :..:|...| :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:.| |.||....
Human   561 VGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWAL 623

  Fly   579 VLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGA 643
            :||..||...|||..|:|:||::|.|||..|:.:|.:....:|.:...|||.|:||:..||.:|.
Human   624 LLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGM 688

  Fly   644 ILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVK 708
            .:|:|:||:.||..|::.......:|..:.|:..:..||...:..:...|..::.:|.....|.|
Human   689 SICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTK 753

  Fly   709 NYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYL--QERAGNWF 767
            |:|||:|||..|..    ..|.|:..|..|.....|.:.|.|:.|:..:.|...|  ::...:..
Human   754 NWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLM 818

  Fly   768 RKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKAL 832
            ...:||||..||.......|...|:|:.|:|.:|.|.::||:...|:.
Human   819 EAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ----------------- 866

  Fly   833 DMYLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDS 895
                                  |:|  .|||.....|
Human   867 ----------------------SEDARAWKTFIGTVR---------------------------- 881

  Fly   896 LSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMP 960
                                                       .::.:.|:.:.   :|::|..|
Human   882 -------------------------------------------VTTAAHLALLV---AKNISFFP 900

  Fly   961 DPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDD 1025
                                                      :::.||    |...|||||:..|
Human   901 ------------------------------------------SNVEQF----SEGNIDVWWIVHD 919

  Fly  1026 GGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDY---------SDL- 1080
            ||:.:|||:::...:.|:.|.:|::.:|.........::.:|:.|...||:.         ||:
Human   920 GGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDIS 984

  Fly  1081 ------TLIPD----------ITKKPQETSTQFFNELIKD--------FVVTEKDGENGT---SS 1118
                  ||:.:          ::|..::...|    |:||        .:.:::|.|..|   ..
Human   985 AYTYERTLMMEQRSQMLRHMRLSKTERDREAQ----LVKDRNSMLRLTSIGSDEDEETETYQEKV 1045

  Fly  1119 RATLNEDDALITD----------DDLLAVQ-DKTN-----RYLRLREYLREQSTKSDLVVMTLPM 1167
            ..|..:|..:.:.          .|||.:: |::|     ..::|.|.:..:|.::.||::.:|.
Human  1046 HMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPG 1110

  Fly  1168 PRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207
            |.:|......||.:||.|:..:...|.|||..:.|:|.||
Human  1111 PPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ncc69	NP_001261758.1	AA_permease_N	144..>183	CDD:285588	12/47 (26%)
		2a30	155..1207	CDD:273347	308/1229 (25%)
		ArsB_NhaD_permease	<524..>682	CDD:304373	56/159 (35%)
		SLC12	724..1207	CDD:281515	96/539 (18%)
SLC12A6	NP_001352017.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..66		7/37 (19%)
		2a30	109..1150	CDD:273347	312/1257 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..181		7/22 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850